Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
From the Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Clin Nucl Med. 2021 Jan;46(1):e31-e33. doi: 10.1097/RLU.0000000000003197.
Three patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent F-THK5351 and C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BPND map and SUV image with F-THK5351 as well as Ki map, Ki/K1 map and SUV image with C-L-deprenyl were created. F-THK5351 BPND maps and SUV images clearly identified the lesions undergoing astrogliosis. C-L-deprenyl Ki/K1 maps were close to F-THK5351 images, but very noisy. Ki maps and SUV images were likely affected by the effect of blood flow. Hence, F-THK5351 is superior to C-L-deprenyl for visualizing lesions undergoing astrogliosis.
三位患有神经紊乱疾病（脑梗死、进行性多灶性白质脑病和多发性硬化症）的患者在同一天接受了 F-THK5351 和 C-L-deprenyl PET 检查，以通过测量 MAO-B 活性来观察星形胶质细胞增生的病变。创建了 F-THK5351 的 BPND 图和 SUV 图像以及 C-L- deprenyl 的 Ki 图、Ki/K1 图和 SUV 图像。F-THK5351 BPND 图和 SUV 图像清楚地识别了星形胶质细胞增生的病变。C-L-deprenyl Ki/K1 图与 F-THK5351 图像接近，但非常嘈杂。Ki 图和 SUV 图像可能受到血流效应的影响。因此，F-THK5351 比 C-L-deprenyl 更适合观察星形胶质细胞增生的病变。
