[Glucose-6-phosphate transformation in the tissues of animals which have received high doses of hydroxythiamine or thiamine].

Administration of hydroxythiamin or thiamin into rats at a dose 400 mg/kg body weight caused a single-directed (unspecific, nonenzymatic) effect on the activity of glucose-6-phosphate and 6-phosphogluconate dehydrogenases within short periods (3-12 hrs). Within 24 and 72 hrs the effects of vitamin and antivitamin acquired the opposite (specific) direction towards the activity of glucose-6-phosphate dehydrogenase in liver tissues. Content of glucose-6-phosphate was altered depending on time of hydroxythiamin effect. Reverse correlation between the activity of glucose-6-phosphate dehydrogenase and content of the substrate was observed in heart muscle either after administration of hydroxythiamin or thiamin; the phenomenon suggest that dehydrogenase reactions affect considerably the regulation of glucose-6-phosphate content in the tissue.