高剂量 8%辣椒素贴片治疗化疗引起的周围神经病。系统评价。
High-Dose 8% Capsaicin Patch in Treatment of Chemotherapy-Induced Peripheral Neuropathy. A Systematic Review.
机构信息
Medical Oncology, Hospital Universitario de Torrejón, Madrid, Spain.
Medical Oncology, Hospital Universitario de Torrejón, Madrid, Spain.
出版信息
J Pain Symptom Manage. 2020 Nov;60(5):1047-1054.e1. doi: 10.1016/j.jpainsymman.2020.06.026. Epub 2020 Jul 10.
INTRODUCTION
This is a review of the evidence from studies of the efficacy and tolerability of topically applied and high-concentration (8%) capsaicin in chemotherapy-induced peripheral neuropathy.
METHODS
For this review, we searched EMBASE and MEDLINE to June 20, 2020. The terms used in the search included capsaicin, capsaicin 8% patch, chemotherapy-induced peripheral neuropathy, and cancer.
RESULTS
A total of 98 studies were obtained, but only five were selected for the final analysis, with a total of 95 patients included. Three of the studies are prospective and two retrospective, including less than 30 patients per study. Capsaicin 8% patch provides significant pain relief in chemotherapy-induced peripheral neuropathy in all of them. However, the small number of studies (and patients) evaluated require caution with these results.
CONCLUSION
Additional clinical trials are required to establish the definitive role of the capsaicin patch in the future.
简介
这是对局部应用和高浓度（8％）辣椒素治疗化疗引起的周围神经病变的疗效和耐受性的研究证据的综述。
方法
为了进行这项综述，我们检索了 EMBASE 和 MEDLINE 数据库，检索时间截至 2020 年 6 月 20 日。检索使用的术语包括辣椒素、8％辣椒素贴片、化疗引起的周围神经病变和癌症。
结果
共获得了 98 项研究，但最终仅选择了 5 项进行分析，共纳入了 95 名患者。其中 3 项为前瞻性研究，2 项为回顾性研究，每项研究的患者少于 30 名。所有研究均表明 8％辣椒素贴片可显著缓解化疗引起的周围神经病变疼痛。然而，评估的研究数量（和患者数量）较少，这些结果需要谨慎对待。
结论
需要开展更多的临床试验以确定辣椒素贴片在未来的明确作用。
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