Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Wulumuqi Road, Shanghai, 200040, China.
Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
BMC Endocr Disord. 2020 Jul 13;20(1):103. doi: 10.1186/s12902-020-00584-7.
To evaluate the association between high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
A cross-sectional study was conducted in 1210 patients with T2DM, among whom 265 had DKD. The severity of DKD was assessed by estimated-glomerular filtration rate (eGFR) and urinary albumin creatinine ratio (ACR). The relationship between ESR, hsCRP and DKD was analyzed by multivariate logistic analysis. The relationship between ESR and eGFR, ESR or ACR was analyzed by multivariate linear regression.
ESR (23.0 [12.0 ~ 41.5] mm/h versus 12.0 [7.0 ~ 22.0] mm/h, P < 0.001) and hsCRP (3.60 [2.20 ~ 7.65] versus 2.90 [1.80 ~ 5.60] mg/L mg/L, P < 0.01) values were significantly higher in patients with DKD than those without. Patients with higher ESR or hsCRP had lower eGFR and higher ACR. After adjusted for gender, age, hemoglobin, plasma proteins, HbA, lipid profiles, and the usage of renin-angiotensin system inhibitors, ESR but not hsCRP was independently associated with the rate and severity of DKD in patients with T2DM.
ESR was independently associated with the rate and severity of DKD in patients with T2DM.
评估高敏 C 反应蛋白（hsCRP）和红细胞沉降率（ESR）与 2 型糖尿病（T2DM）患者糖尿病肾病（DKD）的关系。
对 1210 例 T2DM 患者进行横断面研究，其中 265 例患有 DKD。通过估算肾小球滤过率（eGFR）和尿白蛋白肌酐比（ACR）评估 DKD 的严重程度。采用多变量逻辑分析分析 ESR、hsCRP 与 DKD 的关系。采用多元线性回归分析 ESR 与 eGFR、ESR 或 ACR 的关系。
与无 DKD 患者相比，ESR（23.0[12.041.5]mm/h 比 12.0[7.022.0]mm/h，P<0.001）和 hsCRP（3.60[2.207.65]mg/L 比 2.90[1.805.60]mg/L，P<0.01）值明显升高。ESR 或 hsCRP 较高的患者 eGFR 较低，ACR 较高。在校正性别、年龄、血红蛋白、血浆蛋白、HbA、血脂谱以及肾素-血管紧张素系统抑制剂的使用后，ESR 而不是 hsCRP 与 T2DM 患者 DKD 的发生率和严重程度独立相关。
ESR 与 T2DM 患者 DKD 的发生率和严重程度独立相关。
