Negara Candra Kusuma, Sukartini Tintin, Dewi Yulis Setiya, Pertiwiwati Endang, Chrismilasari Lucia Andi, Arif Rifda Nur Achriyana, Rahmayanti Devi, Maulana Irfan
Doctoral of Nursing Student, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia.
Nursing Science Programs, Faculty of Medicine and Health Sciences, Universitas Lambung, Mangkurat, Banjarmasin, Indonesia.
Iran J Nurs Midwifery Res. 2025 May 8;30(3):373-378. doi: 10.4103/ijnmr.ijnmr_294_23. eCollection 2025 May-Jun.
Diabetes Mellitus (DM) is a metabolic disorder that often leads to diabetic ulcers and persistent hyperglycemia. This condition can cause vascular and metabolic abnormalities, affecting bone marrow performance and altering the hematological profile of patients. This study investigates the correlation between blood glucose levels and hematological profiles in DM patients with diabetic ulcers.
A quantitative, experimental laboratory study was conducted with 30 blood samples from DM patients at Ulin Hospital Banjarmasin, Indonesia, in February 2023, using purposive sampling. Hematological profiles were analyzed with an automatic hematology analyzer, while blood glucose levels were measured using Point-of-Care Testing (POCT). The Erythrocyte Sedimentation Rate (ESR) was assessed by the Westergren method. Pearson and Spearman coefficients were used to compare ESR results at different intervals, and a regression equation was derived to predict conventional ESR values from micro ESR results. Statistical analysis was performed using multiple correlation regression.
The correlation analysis revealed significant relationships between blood glucose and hematological parameters: hemoglobin ( = 0.013), hematocrit ( = 0.011), Mean Corpuscular Volume (MCV) ( = 0.044), and Mean Corpuscular Hemoglobin (MCH) ( = 0.152). No significant correlation was found between blood glucose and the number of erythrocytes ( = 0.997), Mean Corpuscular Hemoglobin Concentration (MCHC) ( = 0.152), total leukocytes ( = 0.082), or platelet count ( = 0.484).
A moderate correlation (r = 0.422) was observed between blood glucose levels and the hematological profile in DM patients with diabetic ulcers.
糖尿病（DM）是一种代谢紊乱疾病，常导致糖尿病溃疡和持续性高血糖。这种情况会引起血管和代谢异常，影响骨髓功能并改变患者的血液学特征。本研究调查糖尿病溃疡的糖尿病患者血糖水平与血液学特征之间的相关性。
2023年2月，在印度尼西亚班贾尔马辛的乌林医院，采用目的抽样法对30例糖尿病患者的血样进行了定量实验性实验室研究。使用自动血液分析仪分析血液学特征，同时使用即时检验（POCT）测量血糖水平。采用魏氏法评估红细胞沉降率（ESR）。使用Pearson和Spearman系数比较不同间隔的ESR结果，并推导回归方程以根据微量ESR结果预测传统ESR值。使用多重相关回归进行统计分析。
相关性分析显示血糖与血液学参数之间存在显著关系：血红蛋白（=0.013）、血细胞比容（=0.011）、平均红细胞体积（MCV）（=0.044）和平均红细胞血红蛋白含量（MCH）（=0.152）。血糖与红细胞数量（=0.997）、平均红细胞血红蛋白浓度（MCHC）（=0.152）、白细胞总数（=0.082）或血小板计数（=0.484）之间未发现显著相关性。
在患有糖尿病溃疡的糖尿病患者中，观察到血糖水平与血液学特征之间存在中度相关性（r = 0.422）。
