Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, PR China.
Crit Rev Food Sci Nutr. 2021;61(14):2399-2410. doi: 10.1080/10408398.2020.1777932. Epub 2020 Jul 14.
Arachidonic acid (ARA), an n-6 essential fatty acid, plays an important role in human and animal growth and development. The ARA presents in the membrane phospholipids can be released by phospholipase A2. These free arachidonic acid molecules are then used to produce eicosanoids through three different pathways. Previous studies have demonstrated that eicosanoids have a wide range of physiological functions. Although they are generally considered to be pro-inflammatory molecules, recent advances have elucidated they have an effect on innate immunity via regulating the development, and differentiation of innate immune cells and the function of the intestinal epithelial barrier. Here, we review eicosanoids generation in intestine and their role in intestinal innate immunity, focusing on intestinal epithelial barrier, innate immune cell in lamina propria (LP) and their crosstalk.
花生四烯酸（ARA），一种 n-6 必需脂肪酸，在人和动物的生长发育中发挥重要作用。存在于膜磷脂中的 ARA 可被磷脂酶 A2 释放。这些游离的花生四烯酸分子随后通过三种不同途径用于生成类二十烷酸。先前的研究表明，类二十烷酸具有广泛的生理功能。尽管它们通常被认为是促炎分子，但最近的进展表明，它们通过调节固有免疫细胞的发育、分化和肠上皮屏障的功能，对固有免疫产生影响。在这里，我们综述了肠内类二十烷酸的生成及其在肠固有免疫中的作用，重点介绍了肠上皮屏障、固有层（LP）中的固有免疫细胞及其相互作用。
