Glaucoma Research Center, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland; Department of Ophthalmology, University of Colorado School of Medicine, Denver, Colorado.
Narayana Nethralaya, Bangalore, India.
Ophthalmology. 2021 Feb;128(2):227-233. doi: 10.1016/j.ophtha.2020.07.016. Epub 2020 Jul 12.
To evaluate the short-term and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma.
Prospective study.
Twenty-two patients previously implanted with a sulcus-based IOP sensor (EyeMate, Implandata GmbH, Germany).
Twenty-two patients previously implanted with the EyeMate were requested to obtain at least 4 IOP measurements daily. Data were grouped according to the eye and the medication so that an eye treated with a particular medication was considered as one group, and the same eye treated with a different medication during the observation period was considered as a different group. A day was divided into 7 periods: night, midnight to 5:59 am; early, 6 am to 7:59 am; morning, 8 am to 10:59 am; noon, 11 am to 1:59 pm; afternoon, 2 pm to 5:59 pm; evening, 6 pm to 8:59 pm; and late, 9 pm to 11:59 pm. Short-term variability during a particular period was defined as the variability in IOP measurements obtained during that period on different days within 3 months of each other. Long-term variability was defined as the variability in IOP measurements obtained during a particular period on different days over a period of 1 year or more. Variability was assessed using intraclass correlation coefficients (ICCs).
The mean age of study participants was 67.8 ± 6.8 years and 36.4% were women. The mean follow-up duration of patients was 19.2 ± 21.3 months (median, 9 months; range, 1-58 months). Overall, 92 860 IOP measurements over 15 811 measurement days were obtained and analyzed during the study period. The number of measurements obtained from each eye ranged from 1 daily to 277 daily. Intraclass correlation coefficients for short-term variability among the 7 periods during the day ranged from 0.52 (morning) to 0.66 (early). Long-term ICCs ranged from 0.29 (night) to 0.51 (late).
Continual IOP monitoring showed that IOP has moderate short-term and high long-term variability in glaucoma patients. These findings demonstrate that single IOP measurements do not characterize day-to-day variations in IOP. Moreover, they show the importance of continual IOP monitoring in glaucoma patients.
评估原发性开角型青光眼患者的眼压（IOP）短期和长期变化。
前瞻性研究。
22 例先前植入巩膜内 IOP 传感器（EyeMate，Implandata GmbH，德国）的患者。
要求 22 例先前植入 EyeMate 的患者每天至少进行 4 次 IOP 测量。根据眼睛和药物将数据分组，以便接受特定药物治疗的眼睛被视为一组，在观察期间接受不同药物治疗的同一眼睛被视为不同组。一天分为 7 个时间段：夜间、午夜至 5:59 am；清晨，6 am 至 7:59 am；上午，8 am 至 10:59 am；中午，11 am 至 1:59 pm；下午，2 pm 至 5:59 pm；傍晚，6 pm 至 8:59 pm；和深夜，9 pm 至 11:59 pm。特定时间段内的短期变异性定义为在 3 个月内的不同日期内获得的该时间段内的 IOP 测量值的变异性。长期变异性定义为在 1 年或更长时间内的不同日期内获得的特定时间段内的 IOP 测量值的变异性。使用组内相关系数（ICCs）评估变异性。
研究参与者的平均年龄为 67.8 ± 6.8 岁，36.4%为女性。患者的平均随访时间为 19.2 ± 21.3 个月（中位数为 9 个月；范围为 1-58 个月）。在研究期间，总共获得并分析了 15811 个测量日的 92860 次 IOP 测量值。每个眼睛的测量次数从每天 1 次到每天 277 次不等。日间 7 个时间段的短期变异性的组内相关系数范围为 0.52（早晨）至 0.66（清晨）。长期 ICC 范围为 0.29（夜间）至 0.51（深夜）。
持续的 IOP 监测表明，青光眼患者的 IOP 具有中度短期和高度长期变异性。这些发现表明，单次 IOP 测量不能描述 IOP 的日常变化。此外，它们表明在青光眼患者中持续进行 IOP 监测的重要性。
