Higashide Tomomi, Udagawa Sachiko, Nakazawa Kazuki, Yamashita Yoko, Tsuchiya Shunsuke, Ohkubo Shinji, Sugiyama Kazuhisa
Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Sci Rep. 2024 Sep 16;14(1):21564. doi: 10.1038/s41598-024-72556-z.
A single-center prospective cohort study was conducted to investigate whether intraocular pressure (IOP)-related 24-h contact lens sensor (CLS) profile parameters can help predict glaucoma progression in patients with normal-tension glaucoma (NTG). CLS measurements (Triggerfish; SENSIMED, Etagnières, Switzerland) at baseline without medication were performed for 24 h in one eye, following diurnal IOP measurements using Goldmann applanation tonometry at 3-h intervals. Glaucoma progression during the follow-up period of ≥ 2 years was determined based on the Guided Progression Analysis of Humphrey visual fields and/or structural progression using fundus photographs. Among 79 patients (mean values: follow-up periods, 48.1 months; age, 51.5 years; baseline IOP, 14.0 mmHg; mean deviation, - 6.04 dB), 23 showed glaucoma progression. A smaller standard deviation of nocturnal ocular pulse amplitude in the CLS profile, a larger range of diurnal IOP at baseline, and the presence of optic disc hemorrhage (DH) during the study period were significant risk factors for glaucoma progression in the multivariate Cox proportional hazards model (hazard ratio, 0.30/mVeq, 1.23/mmHg, and 4.37/presence of DH; P = 0.016, 0.017, and 0.001, respectively). CLS measurements may be useful for assessing the risk of future glaucoma progression in patients with NTG, providing supplementary information to routine IOP measurements.
开展了一项单中心前瞻性队列研究，以调查与眼内压（IOP）相关的24小时隐形眼镜传感器（CLS）轮廓参数是否有助于预测正常眼压性青光眼（NTG）患者的青光眼进展。在未用药的基线状态下，使用戈德曼压平眼压计每3小时进行一次日间眼压测量后，对一只眼睛进行24小时的CLS测量（Triggerfish；SENSIMED，瑞士埃塔尼耶尔）。根据Humphrey视野的引导进展分析和/或使用眼底照片的结构进展情况，确定≥2年随访期内的青光眼进展。在79例患者中（平均值：随访期48.1个月；年龄51.5岁；基线眼压14.0 mmHg；平均偏差-6.04 dB），23例出现青光眼进展。在多变量Cox比例风险模型中，CLS轮廓中夜间眼脉搏振幅的标准差较小、基线时日间眼压范围较大以及研究期间存在视盘出血（DH）是青光眼进展的显著风险因素（风险比分别为0.30/mVeq、1.23/mmHg和4.37/DH存在；P分别为0.016、0.017和0.001）。CLS测量可能有助于评估NTG患者未来青光眼进展的风险，为常规眼压测量提供补充信息。
