Fondation FondaMental, Créteil, France; Aix-Marseille Univ, Faculté de Médecine - Secteur Timone, EA 3279: CEReSS -Centre d'Etude et de Recherche sur les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005 Marseille, France.
Fondation FondaMental, Créteil, France; Aix-Marseille Univ, Faculté de Médecine - Secteur Timone, EA 3279: CEReSS -Centre d'Etude et de Recherche sur les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005 Marseille, France.
J Affect Disord. 2020 Sep 1;274:617-623. doi: 10.1016/j.jad.2020.05.003. Epub 2020 May 19.
Impaired Quality of life (QoL) in schizophrenia has been mostly associated with psychotic and mood symptomatology, insight and functioning so far.
QoL levels remain unsatisfactory due to other factors we aim to explore.
We have explored sleep quality with the Pittsburgh Sleep Quality Index, hostility with the Buss&Perry questionnaire, major depression with the Positive and Negative Syndrome Scale depressive factor, functioning with the Global Assessment of Functioning scale and weight gain with body mass index in addition to other classical QoL-associated factors.
559 patients (mean age=31 (SD 9) years, 74% male sex) were included in the national FACE-SZ cohort. Impaired QoL has been significantly associated with respectively major depression, impaired sleep quality, increased hostility, impaired functioning and impaired insight independently of age, sex, treatments, tobacco smoking and body mass index. Major depression was associated with impaired psychological and physical well-being, and impaired self-esteem. Impaired sleep quality has been associated with impaired psychological and physical well-being and sentimental life. Hostility has been associated with impaired psychological well-being and self-esteem, impaired friends' relationships and impaired autonomy. Weight was associated with impaired physical well-being. Tobacco smoking was associated with higher level of friends' relationships.
Major depression, sleep, hostility, and weight gain have been identified as potential targets to improve QoL in schizophrenia and should be implemented in the recommendations for good practice to optimize schizophrenia care.
迄今为止，精神分裂症患者的生活质量（QoL）受损主要与精神病症状和情绪症状、洞察力和功能有关。
由于我们旨在探索的其他因素，QoL 水平仍然不尽如人意。
我们使用匹兹堡睡眠质量指数（PSQI）来评估睡眠质量，使用 Buss 和 Perry 问卷评估敌意，使用阳性和阴性综合征量表（PANSS）的抑郁因子评估重度抑郁症，使用全球功能评估量表（GAF）评估功能，使用体重指数（BMI）评估体重增加，此外还评估了其他与 QoL 相关的经典因素。
在全国性的 FACE-SZ 队列中，共纳入了 559 名患者（平均年龄为 31 岁，标准差为 9 岁，74%为男性）。生活质量受损与重度抑郁症、睡眠质量差、敌意增加、功能受损和洞察力受损显著相关，这些因素独立于年龄、性别、治疗、吸烟和 BMI。重度抑郁症与心理和身体健康、自尊受损有关。睡眠质量差与心理和身体健康、情感生活受损有关。敌意与心理幸福感和自尊受损、朋友关系受损、自主能力受损有关。体重与身体健康有关。吸烟与朋友关系水平较高有关。
重度抑郁症、睡眠、敌意和体重增加已被确定为改善精神分裂症患者 QoL 的潜在目标，应纳入良好实践建议中，以优化精神分裂症的护理。
