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在一项为期一年的研究中,精神分裂症患者的临床康复与个人康复之间的重叠和相互区别。

Overlap and Mutual Distinctions Between Clinical Recovery and Personal Recovery in People With Schizophrenia in a One-Year Study.

机构信息

Fondation FondaMental, Créteil, France.

Centre Référent de Réhabilitation psychosociale et de Remédiation cognitive (C3R), CH Alpes Isère, Saint Egrève, France.

出版信息

Schizophr Bull. 2022 Mar 1;48(2):382-394. doi: 10.1093/schbul/sbab114.

Abstract

Recovery is a multidimensional construct that can be defined either from a clinical perspective or from a consumer-focused one, as a self-broadening process aimed at living a meaningful life beyond mental illness. We aimed to longitudinally examine the overlap and mutual distinctions between clinical and personal recovery. Of 1239 people with schizophrenia consecutively recruited from the FondaMental Advanced Centers of Expertise for SZ network, the 507 present at one-year did not differ from those lost to follow-up. Clinical recovery was defined as the combination of clinical remission and functional remission. Personal recovery was defined as being in the rebuilding or in the growth stage of the Stages of Recovery Instrument (STORI). Full recovery was defined as the combination of clinical recovery and personal recovery. First, we examined the factors at baseline associated with each aspect of recovery. Then, we conducted multivariable models on the correlates of stable clinical recovery, stable personal recovery, and stable full recovery after one year. At baseline, clinical recovery and personal recovery were characterized by distinct patterns of outcome (i.e. better objective outcomes but no difference in subjective outcomes for clinical recovery, the opposite pattern for personal recovery, and better overall outcomes for full recovery). We found that clinical recovery and personal recovery predicted each other over time (baseline personal recovery for stable clinical recovery at one year; P = .026, OR = 4.94 [1.30-23.0]; baseline clinical recovery for stable personal recovery at one year; P = .016, OR = 3.64 [1.31-11.2]). In short, given the interaction but also the degree of difference between clinical recovery and personal recovery, psychosocial treatment should target, beyond clinical recovery, subjective aspects such as personal recovery and depression to reach full recovery.

摘要

康复是一个多维的概念,可以从临床角度或从以患者为中心的角度进行定义,即自我拓展的过程,旨在摆脱精神疾病,过上有意义的生活。我们旨在从纵向角度研究临床康复和个人康复之间的重叠和相互区别。在从 FondaMental 高级精神分裂症专业中心网络连续招募的 1239 名精神分裂症患者中,有 507 名在一年时仍可随访,他们与失访者没有区别。临床康复定义为临床缓解和功能缓解的结合。个人康复定义为康复阶段量表(STORI)的重建或成长阶段。完全康复定义为临床康复和个人康复的结合。首先,我们检查了基线时与康复各个方面相关的因素。然后,我们对一年后稳定的临床康复、稳定的个人康复和稳定的完全康复的相关因素进行了多变量模型分析。基线时,临床康复和个人康复的结果模式不同(即临床康复的客观结果更好,但主观结果没有差异,个人康复的结果相反,而完全康复的总体结果更好)。我们发现,临床康复和个人康复可以相互预测(基线时的个人康复对一年后的稳定临床康复有预测作用;P =.026,OR = 4.94 [1.30-23.0];基线时的临床康复对一年后的稳定个人康复有预测作用;P =.016,OR = 3.64 [1.31-11.2])。总之,鉴于临床康复和个人康复之间的相互作用以及差异程度,心理社会治疗除了临床康复外,还应针对个人康复和抑郁等主观方面,以达到完全康复。

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