感染HIV的儿童和青少年的相位角与身体成分之间的关联。
Association between Phase Angle and Body Composition of Children and Adolescents Diagnosed with HIV Infection.
作者信息
Martins Priscila Custódio, de Lima Luiz Rodrigo Augustemak, Silva Analiza Mónica, Silva Diego Augusto Santos
机构信息
Research Center in Kinanthropometry and Human Performance, Department of Physical Education, Sports Center, Federal University of Santa Catarina, University Campus-Trindade-n. 476, Florianópolis 88040-900, Santa Catarina, Brazil.
Institute of Physical Education and Sport, Federal University of Alagoas, Campus A.C. Simões, Maceió 57072-900, Alagoas, Brazil.
出版信息
Children (Basel). 2023 Jul 29;10(8):1309. doi: 10.3390/children10081309.
The aim of the study was to investigate how phase angle (PhA) is associated with subtotal and lumbar spine bone mineral density [BMD], lean soft tissue mass [LSTM], total body fat mass, android and gynoid in children and adolescents with HIV according to sex. A cross-sectional study was conducted in Florianópolis, Brazil, involving 64 children and adolescents vertically transmitted with HIV. Resistance and reactance values were obtained using bioelectrical impedance analysis, and PhA was subsequently calculated. Dual emission X-ray absorptiometry was used to assess body composition. Antiretroviral medication, physical activity (accelerometers) and skeletal maturation (wrist-carpal radiography) were used in the adjusted model. In males, PhA was directly associated with subtotal BMD (βadj: 0.65; R²: 0.38, < 0.01) and lumbar spine BMD (βadj: 0.53; R²: 0.22, = 0.01), directly associated with LSTM (βadj: 0.76; R²: 0.46, < 0.01), and inversely associated with gynoid fat (βadj: -0.47; R²: 0.2, = 0.01), in adjusted models. In females, PhA was directly associated with subtotal BMD (βadj: 0.46; R²: 0.17, < 0.01) and lumbar spine BMD (βadj: 0.48; R²: 0.19, < 0.01). It is concluded that PhA was directly associated with subtotal and regional BMD, LSTM, and inversely with gynoid fat in boys with HIV. In girls, PA was directly associated only with subtotal and regional BMD.
该研究的目的是调查在感染艾滋病毒的儿童和青少年中，相位角（PhA）如何根据性别与腰椎和全身骨矿物质密度[BMD]、瘦软组织质量[LSTM]、全身脂肪量、男性型和女性型脂肪相关联。在巴西弗洛里亚诺波利斯进行了一项横断面研究，涉及64名垂直感染艾滋病毒的儿童和青少年。使用生物电阻抗分析获得电阻和电抗值，随后计算PhA。采用双能X线吸收法评估身体成分。在调整模型中使用了抗逆转录病毒药物、身体活动（加速度计）和骨骼成熟度（腕部腕骨X线摄影）。在男性中，在调整模型中，PhA与全身骨密度（βadj：0.65；R²：0.38，<0.01）和腰椎骨密度（βadj：0.53；R²：0.22，=0.01）直接相关，与瘦软组织质量直接相关（βadj：0.76；R²：0.46，<0.01），与女性型脂肪呈负相关（βadj：-0.47；R²：0.2，=0.01）。在女性中，PhA与全身骨密度（βadj：0.46；R²：0.17，<0.01）和腰椎骨密度（βadj：0.48；R²：0.19，<0.01）直接相关。得出的结论是，在感染艾滋病毒的男孩中，PhA与全身和局部骨密度、瘦软组织质量直接相关，与女性型脂肪呈负相关。在女孩中，PhA仅与全身和局部骨密度直接相关。
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