Lee Ui Yun, Kim Chul In, Chung Gyung Ho, Jung Jinmu, Kwak Hyo Sung
Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, Korea.
Department of Radiology and Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.
Diagnostics (Basel). 2020 Jul 12;10(7):473. doi: 10.3390/diagnostics10070473.
To study the effect of the infusion of normal saline on hemodynamic changes in healthy volunteers using computational fluid dynamics (CFD) simulation.
Eight healthy subjects participated and 16 carotid arteries were used for the CFD analysis. A one-liter intravenous infusion of normal saline was applied to the participants to observe the hemodynamic variations. Blood viscosity was measured before and after the injection of normal saline to apply the blood properties on the CFD modeling. Blood viscosity, shear rate, and wall shear stress were visually and quantitatively shown for the comparison between before and after the infusion of normal saline. Statistical analyses were performed to confirm the difference between the before and after groups.
After the infusion of normal saline, decreased blood viscosity was observed in the whole carotid artery. At the internal carotid artery, the recirculation zone with low intensity was found after the injection of normal saline. Increased shear rate and reduced wall shear stress was observed at the carotid bifurcation and internal carotid artery. The hemodynamic differences between before and after groups were statistically significant.
The infusion of normal saline affected not only the overall changes of blood flow in the carotid artery but also the decrease of blood viscosity.
运用计算流体动力学（CFD）模拟研究输注生理盐水对健康志愿者血流动力学变化的影响。
8名健康受试者参与研究，16条颈动脉用于CFD分析。向受试者静脉输注1升生理盐水以观察血流动力学变化。在注射生理盐水前后测量血液粘度，以便将血液特性应用于CFD建模。直观地和定量地展示血液粘度、剪切速率和壁面剪切应力，以比较输注生理盐水前后的情况。进行统计分析以确认前后两组之间的差异。
输注生理盐水后，整个颈动脉的血液粘度降低。在颈内动脉，注射生理盐水后发现强度较低的再循环区域。在颈动脉分叉处和颈内动脉观察到剪切速率增加和壁面剪切应力降低。前后两组之间的血流动力学差异具有统计学意义。
输注生理盐水不仅影响颈动脉血流的整体变化，还影响血液粘度的降低。
