Kim Jin Woo, Kang Ki Soo, Kang Na Ri
Medical Course, Jeju National University School of Medicine, Jeju, Korea.
Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.
Soa Chongsonyon Chongsin Uihak. 2020 Jul 1;31(3):161-164. doi: 10.5765/jkacap.200022.
Crohn's disease is a chronic inflammatory disease that involves the upper and lower gastrointestinal tracts, including the oral cavity. For the conventional treatment of inflammatory bowel diseases, steroids are usually used as induction therapy, and azathioprine is used as maintenance therapy. Steroids are associated with various side effects. Under rare circumstances, they can even cause psychotic symptoms, and reports on steroid-induced psychosis in the pediatric population are few. Here, we report the first case of steroid-induced psychosis in a 16-year-old female with Crohn's disease administered with steroids as induction therapy in South Korea. She showed psychotic symptoms, including auditory hallucination, loosening of association, and idea of reference, after 2 weeks of administering prednisolone 60 mg/day. One week after steroid discontinuation, the patient gradually recovered and was treated with quetiapine. Therefore, pediatricians should be aware of serious psychiatric adverse effects when administering corticosteroids for various indications.
克罗恩病是一种慢性炎症性疾病，累及上、下胃肠道，包括口腔。对于炎症性肠病的传统治疗，通常使用类固醇作为诱导治疗，硫唑嘌呤作为维持治疗。类固醇与各种副作用相关。在罕见情况下，它们甚至可导致精神症状，而关于儿科人群中类固醇所致精神病的报道很少。在此，我们报告韩国首例16岁克罗恩病女性患者在接受类固醇作为诱导治疗后出现类固醇所致精神病。在每日服用60mg泼尼松龙2周后，她出现了精神症状，包括幻听、联想松弛和牵连观念。停用类固醇1周后，患者逐渐康复，并接受了喹硫平治疗。因此，儿科医生在因各种适应证使用皮质类固醇时应意识到严重的精神科不良反应。
