2008-2017 年中国浙江省与呼吸道感染相关的肺炎支原体流行病学和分子鉴定。
Epidemiology and molecular identification of mycoplasma pneumoniae associated with respiratory infections in Zhejiang province, China, 2008-2017.
机构信息
Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Department of Laboratory Center, Huamei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, China.
出版信息
J Clin Lab Anal. 2020 Nov;34(11):e23460. doi: 10.1002/jcla.23460. Epub 2020 Jul 14.
INTRODUCTION
Mycoplasma pneumoniae is a common cause of respiratory infections in humans. The aim of this study was to investigate the infection of Mycoplasma pneumoniae (MP) in patients with acute respiratory tract infections in Zhejiang Province from 2008 to 2017, and to provide evidence for the early diagnosis and prevention of MP pneumonia.
METHODS
MP-DNA was detected in nasopharyngeal swabs of patients with acute respiratory tract infection by real-time fluorescent PCR (TaqMan probe). Statistical analysis and epidemiological investigation were carried out on the test results.
RESULTS
There were 10 296 patients with acute respiratory tract infection in Zhejiang Provincial People's Hospital from 2008 to 2017, including 4387 females and 5909 males. A total of 1251 MP-DNA-positive patients were detected, with a total positive rate of 12.2% (1251/10296). Among 1251 patients with MP infection, 571 were female positive, with an average positive rate of 13.0% (571/4387), and 680 were male positive, with a positive rate of 11.5% (680/5909). From 2008 to 2017, the positive rates were 22.8% (33 cases), 20.9% (211 cases), 20.9% (350 cases), 5.5% (70 cases), 11.7% (136 cases), 15.2% (190 cases), 7.8% (94 cases), 5.9% (62 cases), 7.8% (56 cases), and 6.0% (49 cases), respectively. Of 1251 MP-DNA-positive patients, 1243 (99.4%) were younger than 18 years old.
CONCLUSIONS
Mycoplasma pneumoniae infection mainly occurs from late summer to autumn and in the age below 18 years, suggesting that early diagnosis and prevention of MP infection in adolescents should be emphasized.
简介
肺炎支原体是人类呼吸道感染的常见病原体。本研究旨在调查 2008 年至 2017 年期间浙江省急性呼吸道感染患者肺炎支原体（MP）的感染情况，为 MP 肺炎的早期诊断和预防提供依据。
方法
采用实时荧光 PCR（TaqMan 探针）检测急性呼吸道感染患者鼻咽拭子中的 MP-DNA。对检测结果进行统计学分析和流行病学调查。
结果
2008 年至 2017 年，浙江省人民医院共收治急性呼吸道感染患者 10296 例，其中女性 4387 例，男性 5909 例。共检出 1251 例 MP-DNA 阳性患者，总阳性率为 12.2%（1251/10296）。1251 例 MP 感染患者中，女性阳性 571 例，阳性率为 13.0%（571/4387），男性阳性 680 例，阳性率为 11.5%（680/5909）。2008 年至 2017 年，阳性率分别为 22.8%（33 例）、20.9%（211 例）、20.9%（350 例）、5.5%（70 例）、11.7%（136 例）、15.2%（190 例）、7.8%（94 例）、5.9%（62 例）、7.8%（56 例）、6.0%（49 例）。1251 例 MP-DNA 阳性患者中，1243 例（99.4%）年龄小于 18 岁。
结论
肺炎支原体感染主要发生在夏末秋初和 18 岁以下人群，提示应重视青少年 MP 感染的早期诊断和预防。
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