2017年至2020年西安市53273例呼吸道感染儿童抗体阳性率的实验室分析。

Laboratory analysis of positive rate of antibody among 53,273 children with respiratory tract infections in Xi'an from 2017 to 2020.

作者信息

Meng Gai-Li, Kang Ru, Cheng Xiao-Yue, Wang Qi, Xie Yun

机构信息

Department of Clinical Laboratory, Northwest Women's and Children's Hospital, Xi'an, China.

Department of Clinical Laboratory, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

出版信息

Transl Pediatr. 2022 May;11(5):625-630. doi: 10.21037/tp-22-127.

DOI:10.21037/tp-22-127

PMID:35685083

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9173883/

Abstract

BACKGROUND

() is an important pathogen that causes respiratory tract infections in children. Data on epidemiology of paediatric infection in China are little known. The aim of this study was to investigate the infection of children with respiratory tract infection in Xi'an from 2017 to 2020, and to explore the epidemiological features of paediatric infection in Northwest China during the past 4 years.

METHODS

A total of 53,273 paediatric patients diagnosed with respiratory tract infection as the first diagnosis were enrolled. antibody was detected using passive agglutination method. Statistical analysis and epidemiological investigation were carried out on the test results according to different years, seasons, ages and genders. The differences among rates were analyzed by the χ test. The trends among the rates were analyzed by the Poisson regression.

RESULTS

A total of 14,375 antibody positive patients were detected, with a total positive rate of 26.98%. The rate of infection in 2017 was significantly higher than other years (χ=431.700; P=0.000), and the rate showed a downward trend year by year [incidence rate ratios (IRR) =0.906; 95% CI: 0.892-0.921; P=0.000]. The rate of infection increased gradually in the order of spring, summer, autumn and winter (IRR =1.078; 95% CI: 1.060-1.097; P=0.000), and peaked in winter (29.08%). As age increased, the positive rate of infection also gradually increased (IRR =1.138; 95% CI: 1.134-1.143; P=0.000). The peak age of infection was between 6 and 12 years, accounting for 51.71%, significantly more compared with other age groups (χ=4203.000, P=0.000). Female children had significantly higher positive rates than male children (χ=527.000; P=0.000).

CONCLUSIONS

infection mainly occurs related to year, season, age and gender. Understanding the epidemiological characteristics of paediatric infection can contribute to timely treatment and diagnosis, and may improve the prognosis of children with infection.

摘要

背景

（）是导致儿童呼吸道感染的一种重要病原体。关于中国儿童感染流行病学的数据鲜为人知。本研究旨在调查2017年至2020年西安地区呼吸道感染儿童的感染情况，并探讨过去4年中国西北地区儿童感染的流行病学特征。

方法

共纳入53273例以呼吸道感染为首要诊断的儿科患者。采用被动凝集法检测抗体。根据不同年份、季节、年龄和性别对检测结果进行统计分析和流行病学调查。率之间的差异采用χ检验分析。率的趋势采用泊松回归分析。

结果

共检测到14375例抗体阳性患者，总阳性率为26.98%。2017年的感染率显著高于其他年份（χ=431.700；P=0.000），且该率呈逐年下降趋势[发病率比（IRR）=0.906；95%CI：0.892-0.921；P=0.000]。感染率按春、夏、秋、冬顺序逐渐升高（IRR =1.078；95%CI：1.060-1.097；P=0.000），在冬季达到峰值（29.08%）。随着年龄增长，感染阳性率也逐渐升高（IRR =1.138；95%CI：1.134-1.143；P=0.000）。感染的高峰年龄在6至12岁之间，占51.71%，显著高于其他年龄组（χ=4203.000，P=0.000）。女童的阳性率显著高于男童（χ=527.000；P=0.000）。