Koltzenburg M, McMahon S B
Neurosci Lett. 1986 Dec 23;72(3):352-6. doi: 10.1016/0304-3940(86)90540-9.
In the skin activation of unmyelinated primary afferents produces vasodilation and plasma extravasation. Here, using Evans blue dye leakage, we have quantitatively compared the ability of mechanical, chemical and electrical stimulation of afferents to produce extravasation in the urinary bladder of anaesthetized rats. Mechanical stimulation - a series of large active contractions of vesical smooth muscle induced by maintained distension - elicited no increase in extravasation compared to controls. In contrast, a similar period of electrical stimulation of nerves supplying the bladder, or chemical stimulation with intravesical instillation of mustard oil, produced high levels of extravasation. We conclude that afferents activated during distension and micturition contractions are different from those which produce extravasation. The latter may be important in pathophysiological cases such as inflammation of the urinary bladder.
在皮肤中，无髓鞘初级传入神经的激活会产生血管舒张和血浆外渗。在此，我们使用伊文思蓝染料渗漏法，定量比较了对传入神经进行机械、化学和电刺激在麻醉大鼠膀胱中产生外渗的能力。机械刺激——通过持续扩张诱导膀胱平滑肌一系列强烈的主动收缩——与对照组相比，并未引起外渗增加。相比之下，对膀胱供应神经进行类似时长的电刺激，或膀胱内滴注芥子油进行化学刺激，均产生了高水平的外渗。我们得出结论，在扩张和排尿收缩过程中被激活的传入神经与产生外渗的传入神经不同。后者在诸如膀胱炎症等病理生理情况下可能很重要。
