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Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions.

作者信息

Boonekamp Kim E, Dayton Talya L, Clevers Hans

机构信息

Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, 3584 CT Utrecht, The Netherlands.

Princess Máxima Centre for Paediatric Oncology, 3584 CS Utrecht, The Netherlands.

出版信息

J Mol Cell Biol. 2020 Aug 1;12(8):562-568. doi: 10.1093/jmcb/mjaa034.

DOI:10.1093/jmcb/mjaa034
PMID:32667995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7683021/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfc/7683021/cbc7e56ca985/mjaa034f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfc/7683021/299e8b56f7f3/mjaa034f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfc/7683021/cbc7e56ca985/mjaa034f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfc/7683021/299e8b56f7f3/mjaa034f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfc/7683021/cbc7e56ca985/mjaa034f2.jpg

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Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.通过实时单细胞分化图谱鉴定肠内分泌调节剂。
Cell. 2019 Feb 21;176(5):1158-1173.e16. doi: 10.1016/j.cell.2018.12.029. Epub 2019 Jan 31.
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Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.
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A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research.关于在微生物组研究中确立因果关系、治疗应用及临床前模型使用的共识声明。
Nat Rev Gastroenterol Hepatol. 2025 May;22(5):343-356. doi: 10.1038/s41575-025-01041-3. Epub 2025 Mar 3.
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