Sattar Naveed, Ho Frederick K, Gill Jason Mr, Ghouri Nazim, Gray Stuart R, Celis-Morales Carlos A, Katikireddi S Vittal, Berry Colin, Pell Jill P, McMurray John Jv, Welsh Paul
Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow, G12 8TA, United Kingdom.
Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, G12 8RZ, United Kingdom.
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1149-1151. doi: 10.1016/j.dsx.2020.06.060. Epub 2020 Jun 30.
We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.
Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.
BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (P = 0.03). BMI was more strongly related to test positivity (P = 0.010) and death (P = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.
These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.
我们研究了英国生物银行参与者的体重指数与新冠病毒检测呈阳性的风险以及与新冠病毒相关死亡风险之间的联系。
在4855名在医院接受新冠病毒检测的参与者中，839人检测呈阳性，其中189人死于新冠病毒。使用带惩罚薄板样条的泊松模型，将感兴趣的暴露因素与检测阳性率和病死率相关联，并对混杂因素进行调整。
体重指数与检测呈阳性以及与新冠病毒相关的死亡风险密切相关。与70岁及以上人群相比，70岁以下人群中体重指数相关的风险梯度在新冠病毒相关死亡方面更陡（P = 0.03）。与白人相比，非白人（主要是南亚人和非裔加勒比人）的体重指数与检测阳性率（P = 0.010）和死亡（P = 0.002）的相关性更强。
这些数据支持肥胖与年轻人和非白人种族中与新冠病毒相关的死亡联系更为紧密。如果未来的研究证实因果关系，改善肥胖状况的生活方式干预措施对于降低所有人尤其是非白人社区感染新冠病毒的风险可能很重要。
