Kanto J, Iisalo E, Manell D, Mäntylä R
Int J Clin Pharmacol Biopharm. 1979 Sep;17(9):375-7.
The concentrations of papaverine in the plasma of healthy volunteers were determined by a GLC-method both after single and repeated oral doses of plain and sustained-release drug formulation. In both experiments the AUC-value after the sustained-release drug form was significantly lower than after the plain papaverine and no maintenance of plasma levels for 12 hours after the sustained-release drug form was observed. Our work demonstrates that the systemic availability or papaverine can be markedly affected by product formulation.
采用气相色谱法测定了健康志愿者单次及多次口服普通剂型和缓释剂型罂粟碱后血浆中罂粟碱的浓度。在这两个实验中，缓释剂型后的AUC值显著低于普通罂粟碱剂型，且未观察到缓释剂型后血浆水平维持12小时。我们的研究表明，产品剂型可显著影响罂粟碱的全身可用性。
