Waris T, Hukki J, Lähteenmäki T, Löfstedt T, Kyösola K, van Smitten K
Department of Surgery, Oulu University Central Hospital, Finland.
Scand J Plast Reconstr Surg Hand Surg. 1988;22(3):217-21. doi: 10.3109/02844318809097947.
The regeneration of vascular adrenergic nerves was studied using the glyoxylic acid-induced fluorescence method for the specific demonstration of adrenergic nerves in syngeneic patch-grafts of the right atrium of the heart, vena cava and glutaraldehyde-treated vena cava transplanted into the abdominal aorta of the rat. Glutaraldehyde-treated segments of the supradiaphragmatic inferior vena cava were transplanted into the abdominal aorta of rats as well. At the end of the observation period of 24 weeks limited, patchy and defective innervation was observed in the syngeneic vena cava and atrial patches. No adrenergic nerves were found in the glutaraldehyde-treated vein patch-grafts or vein grafts. Owing to the very poor innervation of atrial and venous patch-grafts the results are not entirely in agreement with the target organ concept of adrenergic nerve regeneration. In this study the suture line around the patch graft probably hampers regeneration of vascular adrenergic nerves in the patches.
利用乙醛酸诱导荧光法研究血管肾上腺素能神经的再生，该方法用于特异性显示移植到大鼠腹主动脉的心脏右心房、腔静脉和戊二醛处理的腔静脉的同基因贴片移植中的肾上腺素能神经。膈上腔静脉经戊二醛处理的节段也移植到大鼠腹主动脉。在24周的观察期结束时，在同基因腔静脉和心房贴片中观察到有限的、片状的和有缺陷的神经支配。在戊二醛处理的静脉贴片移植或静脉移植中未发现肾上腺素能神经。由于心房和静脉贴片移植的神经支配非常差，结果与肾上腺素能神经再生的靶器官概念并不完全一致。在本研究中，贴片移植周围的缝线可能会阻碍贴片中血管肾上腺素能神经的再生。
