自噬相关蛋白Beclin 1与头颈癌

Hu Yang-Jie, Zhong Jiang-Tao, Gong Liang, Zhang Si-Cong, Zhou Shui-Hong

Department of Otolaryngology, The Affiliated Cixi Hospital of Wenzhou Medical University, Cixi 315300, Zhejiang, People's Republic of China.

Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China.

Onco Targets Ther. 2020 Jun 30;13:6213-6227. doi: 10.2147/OTT.S256072. eCollection 2020.

Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and neck cancer, Beclin 1 overexpression promotes autophagy, which limits DNA damage and chromosomal instability and increases necrosis and inflammation by impacting apoptotic and autophagic pathways. This paper reviews the relationship between Beclin 1, carcinogenesis and head and neck cancer prognosis.

自噬的正向调节因子Beclin 1在肿瘤发生过程中表现为一把双刃剑。Beclin 1通过清除有缺陷或受损的细胞器及其他细胞成分来发挥肿瘤抑制作用；然而，其活性也可刺激癌症的起始和进展。在头颈癌中，Beclin 1的过表达促进自噬，这通过影响凋亡和自噬途径限制DNA损伤和染色体不稳定，并增加坏死和炎症。本文综述了Beclin 1、致癌作用与头颈癌预后之间的关系。