Sarin Ankit, Lancaster Elizabeth, Chen Lee-Lynn, Porten Sima, Chen Lee-May, Lager Jeanette, Wick Elizabeth
Department of Surgery, University of California San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94158 USA.
Department of Anesthesia & Perioperative Medicine, University of California San Francisco, 505 Parnassus Ave. M917, San Francisco, CA 94143-0624 USA.
Perioper Med (Lond). 2020 Jul 9;9:21. doi: 10.1186/s13741-020-00153-5. eCollection 2020.
Evidence-based perioperative analgesia is an important tactic for reducing patient exposure to opioids in the perioperative period and potentially preventing new persistent opioid use.
We assessed the impact of a multifaceted optimal analgesia program implemented in the setting of a mature surgical pathway program at an academic medical center. Using existing multidisciplinary workgroups established for continuous process improvement in three surgical pathway areas ((colorectal, gynecology, and urologic oncology (cystectomy)), we developed an educational toolkit focused on implementation strategies for multimodal analgesia and non-pharmacologic approaches for managing pain with the goal of reducing opioid exposure in hospitalized patients. We analyzed prospectively collected data from pathway patients before dissemination of the toolkit (July 2016-June 2017; = 869) and after (July 2017-June 2018; = 838). We evaluated the association between program implementation and use of oral morphine equivalents (OME), average pain scores, time to first ambulation after surgery, urinary catheter duration, time to solid food after surgery, length of stay, discharge opioid prescriptions, and readmission.
Multivariate regression demonstrated that the program was associated with significant decreases in intraoperative OME (14.5 ± 2.4 mEQ (milliequivalents) reduction; < 0.0001), day before discharge OME (18 ± 6.5 mEQ reduction; < 0.005), day of discharge OME (9.6 ± 3.28 mEQ reduction; < 0.003), and discharge prescription OME (156 ± 22 mEq reduction; < 0.001). Reduction in OME was associated with earlier resumption of solid food (0.58 ± 0.15 days reduction; < 0.0002).
Our multifaceted optimal analgesia program to manage perioperative pain in the hospital was effective and further improved analgesia in the setting of a mature enhanced recovery program.
循证围手术期镇痛是减少患者围手术期阿片类药物暴露并可能预防新的持续性阿片类药物使用的重要策略。
我们评估了在一所学术医疗中心成熟的手术路径项目背景下实施的多方面优化镇痛方案的影响。利用为三个手术路径领域(结直肠、妇科和泌尿外科肿瘤(膀胱切除术))持续改进流程而设立的现有多学科工作组,我们开发了一个教育工具包,重点关注多模式镇痛的实施策略和管理疼痛的非药物方法,目标是减少住院患者的阿片类药物暴露。我们前瞻性分析了工具包分发前(2016年7月至2017年6月;n = 869)和分发后(2017年7月至2018年6月;n = 838)路径患者的数据。我们评估了项目实施与口服吗啡当量(OME)使用、平均疼痛评分、术后首次下床活动时间、导尿管留置时间、术后开始进食固体食物时间、住院时间、出院时阿片类药物处方以及再入院之间的关联。
多变量回归表明,该方案与术中OME显著降低(减少14.5±2.4 mEQ(毫当量);P < 0.0001)、出院前一天OME(减少18±6.5 mEQ;P < 0.005)、出院当天OME(减少9.6±3.28 mEQ;P < 0.003)以及出院处方OME(减少156±22 mEq;P < 0.001)相关。OME的减少与更早恢复进食固体食物(减少0.58±0.15天;P < 0.0002)相关。
我们在医院管理围手术期疼痛的多方面优化镇痛方案是有效的,并在成熟的强化康复方案背景下进一步改善了镇痛效果。