Faculty of Medicine, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
"Sf. Spiridon" University Hospital, 700111 Iasi, Romania.
Cardiovasc Ther. 2019 Sep 2;2019:9402781. doi: 10.1155/2019/9402781. eCollection 2019.
The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. Numerous studies and case reports showed various pharmacokinetic interactions that are characterized by a high degree of unpredictability. This review highlights the pharmacokinetic clinically relevant interactions between major conventional cardiovascular medicines and plant products with an emphasis on their putative mechanisms, drawbacks of herbal products use, and the perspectives for further well-designed studies.
在心血管药物治疗的患者中，植物产品的使用日益增加，这引起了人们对它们与传统心血管药物潜在相互作用的关注。植物产品可能会影响同时使用的药物的药代动力学或/和药理活性，其中一些相互作用可能导致意想不到的临床结果。许多研究和病例报告显示了各种药代动力学相互作用，其特征是高度不可预测性。本综述强调了主要常规心血管药物与植物产品之间具有临床相关性的药代动力学相互作用，并重点介绍了它们的潜在机制、草药产品使用的缺点以及进一步进行精心设计的研究的前景。
