Berkenstock Meghan, Patel Shaivi, Ackert Jessica
Division of Ocular Immunology, Wilmer Eye Institute, Johns Hopkins School of Medicine, MD, USA.
Drexel University College of Medicine, Philadelphia, PA, USA.
J Curr Ophthalmol. 2020 Apr 30;32(2):195-198. doi: 10.4103/JOCO.JOCO_103_20. eCollection 2020 Apr-Jun.
To describe the association of change in the baseline hemoglobin levels with the development of interferon (INF) retinopathy after the start of pegylated INF (PEG INF) and ribavirin for hepatitis C virus treatment.
This was a retrospective chart review conducted on 12 patients on PEG INF and ribavirin with baseline examination and follow-up during the treatment regimen: 6 developed INF-induced retinopathy and 6 patients were without retinopathy. Serial hemoglobin values for both the groups were recorded at the time of the retinopathy diagnosis in affected patients and the nadir in those without retinopathy. The total percent reduction of hemoglobin was calculated for both the groups.
Hemoglobin concentration levels between control and INF retinopathy patients tended to be slightly lower in the group that developed retinopathy. There was no threshold hemoglobin concentration under which the rate of developing retinopathy significantly increased. Greater than 25% drop in hemoglobin conferred a statistically significant risk in the development of INF-associated retinopathy.
Patients starting PEG INF and ribavirin require baseline testing and subsequent follow-up based on the rapidity of the decrease in hemoglobin levels to identify the development of retinopathy with treatment.
描述在开始使用聚乙二醇干扰素（PEG INF）和利巴韦林治疗丙型肝炎病毒后，基线血红蛋白水平的变化与干扰素（INF）视网膜病变发生之间的关联。
这是一项对12例接受PEG INF和利巴韦林治疗的患者进行的回顾性病历审查，在治疗方案期间进行了基线检查和随访：6例发生了INF诱导的视网膜病变，6例患者未发生视网膜病变。在受影响患者的视网膜病变诊断时以及未发生视网膜病变患者的最低点记录两组的系列血红蛋白值。计算两组血红蛋白的总降低百分比。
发生视网膜病变的组中，对照组和INF视网膜病变患者之间的血红蛋白浓度水平往往略低。没有一个阈值血红蛋白浓度，低于该浓度时视网膜病变的发生率会显著增加。血红蛋白下降超过25%在INF相关视网膜病变的发生中具有统计学显著风险。
开始使用PEG INF和利巴韦林治疗的患者需要进行基线检测，并根据血红蛋白水平下降的速度进行后续随访，以确定治疗过程中视网膜病变的发生情况。
