多发性硬化症中的α1-抗胰蛋白酶（Pi）类型以及与免疫球蛋白（Gm）标记物缺乏相互作用

Alpha-1-antitrypsin (Pi) types in multiple sclerosis and lack of interaction with immunoglobulin (Gm) markers.

作者信息

Francis D A, Klouda P T, Brazier D M, Batchelor J R, McDonald W I, Hern J E

机构信息

Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

出版信息

J Immunogenet. 1988 Oct-Dec;15(5-6):251-5. doi: 10.1111/j.1744-313x.1988.tb00428.x.

DOI:10.1111/j.1744-313x.1988.tb00428.x

PMID:3267150

Abstract

Susceptibility to multiple sclerosis is thought to involve several genetic loci apart from the HLA region on chromosome 6. No Pi allotype nor phenotype was associated with the disease in 125 unrelated patients from the Grampian region of northeast Scotland. Despite a previously reported Gm-HLA association in this population there was no apparent interaction between Pi alleles and Gm type which influenced disease susceptibility.

摘要

除了6号染色体上的HLA区域外，多发性硬化症的易感性还被认为涉及几个基因位点。在来自苏格兰东北部格兰扁地区的125名无亲缘关系的患者中，未发现Pi同种异型或表型与该疾病有关。尽管此前报道了该人群中Gm与HLA的关联，但Pi等位基因与影响疾病易感性的Gm类型之间没有明显的相互作用。