类风湿关节炎和早发性慢性活动性肝炎中的免疫球蛋白（Gm）标记物及α1-抗胰蛋白酶（PI）类型

Immunoglobulin (Gm) markers and alpha 1-antitrypsin (PI) types in rheumatoid arthritis and early onset chronic active hepatitis.

作者信息

Walsh L J, Cox D W

出版信息

J Immunogenet. 1984 Apr;11(2):115-20. doi: 10.1111/j.1744-313x.1984.tb01045.x.

DOI:10.1111/j.1744-313x.1984.tb01045.x

Abstract

No Gm allotype, haplotype or phenotype was increased or decreased in frequency in two autoimmune diseases, rheumatoid arthritis (RA) or chronic active hepatitis (CAH) in comparison with control frequencies. The frequencies of the Gm haplotypes among 206 controls were 0.70, 0.19 and 0.11 for fb, ag and axg , respectively. Neither Gm heterozygosity nor homozygosity was associated with either disease. There was no interaction between alpha 1-antitrypsin (PI) and Gm type in the two diseases.

摘要

与对照频率相比，在类风湿性关节炎（RA）或慢性活动性肝炎（CAH）这两种自身免疫性疾病中，没有Gm同种异型、单倍型或表型的频率增加或减少。在206名对照中，fb、ag和axg的Gm单倍型频率分别为0.70、0.19和0.11。Gm杂合性和纯合性均与这两种疾病无关。在这两种疾病中，α1-抗胰蛋白酶（PI）和Gm类型之间没有相互作用。