Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital London Health Sciences Centre, Western University, London, Canada.
Department of Pediatrics, University of Illinois College of Medicine, Peoria, Illinois.
Pediatr Blood Cancer. 2020 Sep;67(9):e28361. doi: 10.1002/pbc.28361. Epub 2020 Jul 16.
Waldeyer's ring (WR) involvement in pediatric Hodgkin lymphoma (HL) is extremely rare and criteria for determining involvement and response to treatment are unclear. The international Staging, Evaluation, and Response Criteria Harmonization for Childhood, Adolescent and Young Adult Hodgkin Lymphoma (SEARCH for CAYAHL) Group performed a systematic review of the literature in search of involvement or response criteria, or evidence to support specific criteria. Only 166 cases of HL with WR involvement were reported in the literature, 7 of which were pediatric. To date no standardized diagnostic or response assessment criteria are available. Given the paucity of evidence, using a modified Delphi survey technique, expert consensus statements were developed by the SEARCH group to allow for a more consistent definition of disease and response evaluation related to this rare site of involvement among pediatric oncologists. The available evidence and expert consensus statements are summarized.
瓦尔德耶尔环（WR）参与儿科霍奇金淋巴瘤（HL）极为罕见，且其受累和治疗反应的评估标准尚不清楚。国际儿童、青少年和年轻成人霍奇金淋巴瘤分期、评估和疗效标准协调（SEARCH for CAYAHL）小组对文献进行了系统回顾，以寻找受累或反应标准，或支持特定标准的证据。文献中仅报道了 166 例 WR 受累的 HL，其中 7 例为儿科病例。迄今为止，尚无标准化的诊断或反应评估标准。鉴于证据不足，SEARCH 小组采用改良 Delphi 调查技术制定了专家共识声明，以便儿科肿瘤学家能够更一致地定义与该罕见受累部位相关的疾病和反应评估。总结了现有证据和专家共识声明。
