Regional University of Cariri (URCA), Crato, CE, Brazil.
Federal University of Paraná (UFPR), Curitiba, PR, Brazil.
Z Naturforsch C J Biosci. 2020 Jul 16;76(1-2):35-42. doi: 10.1515/znc-2020-0045. Print 2021 Jan 27.
The objective of this study was to determine the chemical profile and to evaluate the antibacterial activity of the essential oils of species and modulation of the antibiotic activity, using the microdilution method to determine the minimum inhibitory concentration. The chemical components were characterized by gas chromatography coupled to mass spectrometry, which revealed β-copaen-4-α-ol (31.38%), spathulenol (25.92%), and germacrene B (21.53%) as major constituents of the essential oils of , , respectively. The essential oils analyzed in this study did not present a clinically relevant activity against standard and multiresistant . However, in the case of multiresistant , there was a significant activity, corroborating with reports in the literature, where Gram-positive bacteria are more susceptible to antimicrobial activity. The essential oils modulated the effect of the antibiotics norfloxacin and gentamicin, having on the latter greater modulating effect; however, for erythromycin, no statistically significant effect was observed. In conclusion, the results obtained in this study demonstrated that the essential oils of the analyzed species present an inhibitory effect against and modulate antibiotic activity, most of which presents synergistic activity.
本研究旨在确定 种植物精油的化学成分，并评估其抗菌活性，采用微量稀释法测定最小抑菌浓度。通过气相色谱-质谱联用技术对化学成分进行了表征，结果表明， 种植物精油的主要成分分别为β-古巴烯-4-α-醇（31.38%）、斯巴醇（25.92%）和大根香叶烯 B（21.53%）。本研究分析的精油对标准和多耐药 没有表现出临床相关的活性。然而，在多耐药 的情况下，存在显著的活性，与文献中的报道一致，即革兰氏阳性菌对抗菌活性更敏感。精油对诺氟沙星和庆大霉素的作用具有调节作用，对后者的调节作用更强；然而，对于红霉素，没有观察到统计学上显著的作用。总之，本研究的结果表明，分析的 种植物精油对 具有抑制作用，并调节抗生素活性，其中大部分具有协同活性。
