Paredes-Lopez D M, Robles-Huaynate R A, Perales-Camacho R A, Alania-Santiago C V, Diaz-Gonzales J P, Aldava-Pardave U
Department of Animal Science, Universidad Nacional Agraria de la Selva, Tingo María, Peru.
Department of Animal and Public Health, Faculty of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Front Vet Sci. 2025 May 27;12:1597948. doi: 10.3389/fvets.2025.1597948. eCollection 2025.
High-level use of antibiotics as grow promotors in animal nutrition in the last six decades has pushed to bacterial resistance to these molecules. The search for alternative ways including plants extracts, essential oils or phytochemicals to tackle this problem is increasing nowadays. This study aimed to evaluate the effects of polyphenols (PaP) and flavonoids (PaF) on broiler chicken gut health. 396 Cobb 500 broiler chickens aged 1-33 d old were fed a base diet (BD). Birds were randomly divided into two control (C) and four supplementations (S) groups. C1 was fed with BD and C2 with BD + 50 ppm zinc bacitracin. S1 and S2 were supplemented with 17.5 and 35.0 ppm PaP, whereas S3 and S4 were supplemented with 17.5 and 35.0 ppm PaF of the diet, respectively and sub ministered in drinking water from 1-21 d of age. The gut microbiota at 21 and 28 d of age, gut villi histomorphometry at 7, 14, and 21 d and performance indices at 7, 21 and 33 d were evaluated. Data was processed using a general factorial arrangement. PaP and PaF supplementation, increased lymphocytes and globulins in chickens at 14 d of age ( < 0.05), at the same time erythrocytes, granulocytes, and ALT profiles decreased at 21 d of age ( < 0.05). and abundance (log CFU/g) decreased, sp. was enhanced in ileal mucosa and content of chickens at 21 d old on supplementation 35.0 ppm PaP, 17.5 and 35.0 ppm of PaF ( < 0.05) and villi length increased with the age of chickens supplemented 17.5 ppm of PaP, 17.5 and 35.0 ppm of PaF ( < 0.05). As a result, PaP and PaF maintain weight gain and feed conversion rate, reduce feed intake and improve carcass yield overall in the three stages of broiler chickens. In conclusion, PaP and PaF enhanced gut health, the immune and anti-inflammatory activity, and performance indices of broiler chickens.
在过去的六十年里，在动物营养中高水平使用抗生素作为生长促进剂导致了细菌对这些分子产生耐药性。如今，人们越来越多地寻找包括植物提取物、精油或植物化学物质在内的替代方法来解决这个问题。本研究旨在评估多酚（PaP）和黄酮类化合物（PaF）对肉鸡肠道健康的影响。将396只1至33日龄的科宝500肉鸡饲喂基础日粮（BD）。将鸡随机分为两个对照组（C）和四个添加组（S）。C1组饲喂基础日粮，C2组饲喂基础日粮+50 ppm杆菌肽锌。S1和S2组分别在日粮中添加17.5和35.0 ppm的PaP，而S3和S4组分别在日粮中添加17.5和35.0 ppm的PaF，并在1至21日龄期间通过饮水给予。评估了21日龄和28日龄时的肠道微生物群、7日龄、14日龄和21日龄时的肠道绒毛组织形态计量学以及7日龄、21日龄和33日龄时的生产性能指标。数据采用一般析因设计进行处理。添加PaP和PaF可使14日龄鸡的淋巴细胞和球蛋白增加（P<0.05），同时21日龄时红细胞、粒细胞和谷丙转氨酶水平降低（P<0.05）。添加35.0 ppm PaP、17.5和35.0 ppm PaF后，21日龄鸡回肠黏膜和内容物中的大肠杆菌丰度（log CFU/g）降低，乳酸杆菌属得到增强（P<0.05），并且添加17.5 ppm PaP、17.5和35.0 ppm PaF的鸡的绒毛长度随鸡龄增加（P<0.05）。结果，在肉鸡的三个阶段，PaP和PaF总体上维持了体重增加和饲料转化率，降低了采食量并提高了胴体产量。总之，PaP和PaF增强了肉鸡的肠道健康、免疫和抗炎活性以及生产性能指标。
