Emergency Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Caversham Rehabilitation Ward, Royal Berkshire Hospital, Reading, UK.
Environ Toxicol Pharmacol. 2020 Nov;80:103456. doi: 10.1016/j.etap.2020.103456. Epub 2020 Jul 13.
This study explores the efficacy and mechanism by which octreotide (OCT) alleviates paraquat (PQ)-induced pancreatic injury. Twenty-four adult male rats were randomly divided into three groups: the normal control (NC), PQ poisoning, and OCT treatment groups. The PQ-induced pancreatic injury rat model was established by administering PQ (120 mg/kg). Treatment group rats received OCT (8 μg/kg body weight) every 8 h by subcutaneous injection, 1 h after PQ administration. Rats were euthanized 24 h after PQ injection. Serum amylase, lipase, tumor necrosis factor-α, and interleukin-6 levels were markedly increased in the PQ group versus the NC group. In pancreatic tissue, PQ poisoning drastically induced necrosis and increased inflammatory cytokine and oxidative stress marker levels. Compared with the PQ group, OCT reduced pancreatic damage and histological scores, serum amylase, lipase, and inflammatory cytokine levels, as well as oxidative stress. OCT demonstrates protective effects against PQ-induced pancreatic damage through anti-inflammatory and antioxidant actions.
本研究探讨了奥曲肽（OCT）缓解百草枯（PQ）诱导的胰腺损伤的疗效和机制。将 24 只成年雄性大鼠随机分为三组：正常对照组（NC）、PQ 中毒组和 OCT 治疗组。通过给予 PQ（120mg/kg）建立 PQ 诱导的胰腺损伤大鼠模型。治疗组大鼠在 PQ 给药后 1 小时通过皮下注射 OCT（8μg/kg 体重），每 8 小时一次。大鼠在 PQ 注射后 24 小时处死。与 NC 组相比，PQ 组大鼠血清淀粉酶、脂肪酶、肿瘤坏死因子-α和白细胞介素-6 水平明显升高。在胰腺组织中，PQ 中毒强烈诱导坏死，并增加炎症细胞因子和氧化应激标志物水平。与 PQ 组相比，OCT 降低了胰腺损伤和组织学评分、血清淀粉酶、脂肪酶和炎症细胞因子水平以及氧化应激。OCT 通过抗炎和抗氧化作用显示出对 PQ 诱导的胰腺损伤的保护作用。
