Department of Biology, University of Florence, 50019, Sesto Fiorentino, Italy.
Department of Biology, University of Florence, 50019, Sesto Fiorentino, Italy.
Microbiol Res. 2020 Nov;240:126555. doi: 10.1016/j.micres.2020.126555. Epub 2020 Jul 9.
Histidine biosynthesis is an ancestral pathway that was assembled before the appearance of the Last Universal Common Ancestor; afterwards, it remained unaltered in all the extant histidine-synthesizing (micro)organisms. It is a metabolic cross-road interconnecting histidine biosynthesis to nitrogen metabolism and the de novo synthesis of purines. This interconnection is due to the reaction catalyzed by the products of hisH and hisF genes. The latter gene is an excellent model to study which trajectories have been followed by primordial cells to build the first metabolic routes, since its evolution is the result of different molecular rearrangement events, i.e. gene duplication, gene fusion, gene elongation, and domain shuffling. Additionally, this review summarizes data concerning the involvement of hisF and its product in other different cellular processes, revealing that HisF very likely plays a role also in cell division control and involvement in virulence and nodule development in different bacteria. From the metabolic viewpoint, these results suggest that HisF plays a central role in cellular metabolism, highlighting the interconnections of different metabolic pathways.
组氨酸生物合成是一种古老的途径，它在最后普遍共同祖先出现之前就已经形成；此后，它在所有现存的合成组氨酸的（微生物）中保持不变。它是一个代谢交叉路口，将组氨酸生物合成与氮代谢和嘌呤的从头合成连接起来。这种连接是由 hisH 和 hisF 基因产物催化的反应引起的。后者是研究原始细胞为构建第一条代谢途径而遵循的轨迹的绝佳模型，因为它的进化是不同分子重排事件的结果，即基因复制、基因融合、基因延长和结构域改组。此外，这篇综述总结了有关 hisF 及其产物参与其他不同细胞过程的数据，表明 HisF 很可能在细胞分裂控制以及在不同细菌的毒力和根瘤发育中发挥作用。从代谢的角度来看，这些结果表明 HisF 在细胞代谢中起着核心作用，突出了不同代谢途径的相互联系。
