Zelikoff J T, Atkins N M, Belman S
Institute of Environmental Medicine, New York University Medical Center, New York 10016.
Cell Biol Toxicol. 1986 Sep;2(3):369-78. doi: 10.1007/BF00121852.
Onion and garlic oil were seen to shorten the cell-doubling time and stimulate the growth and proliferation of NIH-3T3 cells. Following treatment with either onion or garlic oil, an increase in the growth rate and almost a 2-fold increase in cell number over the control was observed within a 24-hour period. Phorbol myristate acetate when given simultaneously with either oil appeared to nullify both effects. Following exposure to low doses (less than 10 micrograms/ml) of either oil, an increase in cell survival, not seen with the oil control tricaprylin, was observed following a 5-day exposure period. At higher concentrations cell survival decreased proportionately in all cases. The appearance of multinucleated cells, which increased with dose and time, was also observed following treatment with both garlic and onion oil.
洋葱油和大蒜油可缩短细胞倍增时间，并刺激NIH-3T3细胞的生长和增殖。用洋葱油或大蒜油处理后，在24小时内观察到生长速率增加，细胞数量比对照增加了近两倍。当与任何一种油同时给予佛波醇肉豆蔻酸酯时，似乎会抵消这两种作用。在暴露于低剂量（低于10微克/毫升）的任何一种油后，经过5天的暴露期，观察到细胞存活率增加，而对照油三辛酸甘油酯则未出现这种情况。在所有情况下，浓度较高时细胞存活率会相应降低。在用大蒜油和洋葱油处理后，还观察到多核细胞的出现，其数量随剂量和时间增加。
