Kawai K, Mori H, Sugie S, Yoshimi N, Inoue T, Nakamaru T, Nozawa Y, Matsushima T
Department of Food and Nutrition, Faculty of Home Economics, Chukyo Women's University, Aichi, Japan.
Cell Biol Toxicol. 1986 Dec;2(4):457-67. doi: 10.1007/BF00117848.
1-Hydroxyanthraquinone and dihydroxyanthraquinones (alizarin, quinizarin, anthrarufin and chrysazin) were examined for genotoxicity in the hepatocyte/DNA repair test and for effects on oxidative phosphorylation in isolated rat liver mitochondria. Of the anthraquinone compounds tested, 1-hydroxyanthraquinone and 1,8-dihydroxyanthraquinone (chrysazin) induced DNA repair synthesis in rat hepatocytes, indicating their genotoxic activity. Only 1,2-dihydroxyanthraquinone (alizarin) exerted an uncoupling and inhibitory effect on mitochondrial respiration. The possible relationships of the genotoxic potencies and the uncoupling activities of these anthraquinones to their chemical structures are discussed.
在肝细胞/DNA修复试验中检测了1-羟基蒽醌和二羟基蒽醌（茜素、醌茜素、蒽 Rufin 和 Chrysazin）的遗传毒性，并研究了它们对分离的大鼠肝线粒体氧化磷酸化的影响。在所测试的蒽醌化合物中，1-羟基蒽醌和1,8-二羟基蒽醌（Chrysazin）诱导大鼠肝细胞的DNA修复合成，表明它们具有遗传毒性活性。只有1,2-二羟基蒽醌（茜素）对线粒体呼吸有解偶联和抑制作用。讨论了这些蒽醌的遗传毒性潜力和解偶联活性与其化学结构之间的可能关系。
