蒽醌和羟基化蒽醌在艾姆斯/沙门氏菌微粒体系统中的致突变性。
Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system.
作者信息
Liberman D F, Fink R C, Schaefer F L, Mulcahy R J, Stark A A
出版信息
Appl Environ Microbiol. 1982 Jun;43(6):1354-9. doi: 10.1128/aem.43.6.1354-1359.1982.
Abstract
The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay. Anthraquinone was shown to be mutagenic for strains TA1537, TA1538, and TA98 in the absence of rat liver homogenate. The four anthraquinone derivatives tested were mutagenic for TA1537 exclusively. None of the anthracenes exhibited mutagenic activity.
摘要
在艾姆斯/沙门氏菌微粒体试验中评估了蒽、蒽醌以及它们各自的四种结构相似化合物的致突变性。结果表明，在没有大鼠肝匀浆的情况下，蒽醌对TA1537、TA1538和TA98菌株具有致突变性。所测试的四种蒽醌衍生物仅对TA1537具有致突变性。所有蒽类化合物均未表现出致突变活性。
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