Zhu Jun, Lu Liyu, Zhong Min, Jiang Xu, Wu Zhuang, Dong Jingde, Pan Yang, Zhang Li
Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.
Neurol Sci. 2021 Mar;42(3):961-968. doi: 10.1007/s10072-020-04597-x. Epub 2020 Jul 16.
Impaired rapid eye movement sleep is common among patients with Parkinson's disease (PD). However, information on rapid eye movement density (REM) among PD patients is currently lacking. The current study sought to characterize REM density in PD patients and to examine the associations between REM density sleep parameters and clinical manifestations.
We retrospectively recruited 172 PD patients. All participants were assessed with a two-night polysomnography, and REM density was calculated. Clinical assessments were completed in PD patients before polysomnography.
Rapid eye movement sleep behavior disorder (RBD) was observed in 93 patients (54.1%). The disease duration, UPDRS part III score, Hoehn and Yahr (H-Y) stage, and HAMA, HAMD, PDQ-39 scores, and REM density in the Parkinson's disease patients with rapid eye movement sleep behavior disorder (RBD) were significantly higher than in the patients without RBD (P < 0.05). However, NREM sleep stage 3 time (N3 time) and percentage of N3 time of total sleep time (N3%) were significantly lower in the RBD patients than in the patients without RBD (P < 0.05). The forward binary logistic regression model showed that REM density, UPDRS-III score, and N3 sleep time were associated with RBD in the PD patients.
Our results confirm the high prevalence of RBD in patients with PD. Increased REM density was the main risk factor of RBD.
快速眼动睡眠障碍在帕金森病（PD）患者中很常见。然而，目前缺乏关于PD患者快速眼动密度（REM）的信息。本研究旨在描述PD患者的REM密度特征，并探讨REM密度睡眠参数与临床表现之间的关联。
我们回顾性招募了172例PD患者。所有参与者均接受了为期两晚的多导睡眠图检查，并计算REM密度。在进行多导睡眠图检查前，对PD患者完成了临床评估。
93例患者（54.1%）观察到快速眼动睡眠行为障碍（RBD）。帕金森病合并快速眼动睡眠行为障碍（RBD）患者的病程、统一帕金森病评定量表第三部分（UPDRS part III）评分、霍恩和雅尔（H-Y）分期、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、帕金森病问卷-39项（PDQ-39）评分及REM密度显著高于无RBD患者（P<0.05）。然而，RBD患者的非快速眼动睡眠3期时间（N3时间）及N3时间占总睡眠时间的百分比（N3%）显著低于无RBD患者（P<0.05）。向前二元逻辑回归模型显示，PD患者的REM密度、UPDRS-III评分及N3睡眠时间与RBD相关。
我们的结果证实了RBD在PD患者中的高患病率。REM密度增加是RBD的主要危险因素。
