College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
AAPS PharmSciTech. 2020 Jul 16;21(5):199. doi: 10.1208/s12249-020-01715-y.
A new transdermal drug delivery system of nanofiber membrane with good biocompatibility and high drug loading was developed by electrospinning technology in this study. Using vinyl alcohol-co-ethylene (PVA-co-PE) polymer as a spinning matrix and non-steroidal anti-inflammatory drug (NSAID) sulindac (SUL) as a model drug, the SUL@PVA-co-PE nanofiber membrane was prepared and characterized systematically. The morphology, molecular vibrational transitions, thermogravimetric attributes, and in vitro drug release and transdermal characteristics of drug-loaded nanofiber membranes were analyzed. The results indicated that the surface of PVA-co-PE nanofibers was uniform and smooth with the diameter ranged from 461 to 696 nm. Notably in vitro simulation experiments demonstrated that SUL@PVA-co-PE nanofiber membrane could provide a continuous drug release to reach the effective concentration of the drug, and exhibited significantly higher cumulative drug permeability compared to commercially available patches, Taken together, PVA-co-PE nanofiber membranes exhibited the characteristics of high drug loading and stability, and represented the potential to be utilized as a new transdermal drug delivery carrier with pronounced development prospect.
本研究采用静电纺丝技术开发了一种具有良好生物相容性和高载药量的新型纳米纤维膜透皮给药系统。以乙烯醇-共-乙烯（PVA-co-PE）聚合物为纺丝基体，以非甾体抗炎药（NSAID）舒林酸（SUL）为模型药物，系统制备并表征了 SUL@PVA-co-PE 纳米纤维膜。分析了载药纳米纤维膜的形貌、分子振动跃迁、热重属性以及体外药物释放和透皮特性。结果表明，PVA-co-PE 纳米纤维的表面均匀光滑，直径范围为 461 至 696nm。值得注意的是，体外模拟实验表明，SUL@PVA-co-PE 纳米纤维膜可以提供持续的药物释放以达到药物的有效浓度，并且与市售贴片相比表现出明显更高的累积药物透过率。综上所述，PVA-co-PE 纳米纤维膜具有高载药量和稳定性的特点，有望成为一种新型的透皮给药载体，具有显著的发展前景。
