School of Materials Science and Engineering, Hebei University of Technology; Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, Tianjin 300130, People's Republic of China.
Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China.
Nanotechnology. 2021 Jan 1;32(1):015101. doi: 10.1088/1361-6528/abb55a.
Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy.
静电纺丝复合纳米纤维支架被认为是局部药物输送的潜在载体，可防止肿瘤复发。在此，将模型药物（紫杉醇）创造性地负载到木质素纳米颗粒（PLNPs）中，然后包封到已制备成复合纳米纤维膜（PVA/PVP-PLNPs）的聚合物聚（聚乙烯醇）/聚乙烯吡咯烷酮中，用作药物载体使用静电纺丝技术。所制备的 PVA/PVP-PLNPs 膜表现出良好的颗粒分布、力学性能、热稳定性和生物相容性。体外实验表明，通过静电纺丝将木质素纳米颗粒结合在一起，不仅改善了药物释放曲线，还提高了纳米纤维膜的亲水性，有利于细胞黏附和增殖。细胞实验表明，PVA/PVP-2%PLNPs 膜具有良好的细胞抑制能力，第 7 天时细胞存活率仅为 21%。这表明所制备的 PVA/PVP-PLNPs 复合纳米纤维有望成为局部抗癌治疗的候选材料。
