ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands.
Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Nat Med. 2020 Sep;26(9):1405-1410. doi: 10.1038/s41591-020-0997-y. Epub 2020 Jul 16.
In late December 2019, a cluster of cases of pneumonia of unknown etiology were reported linked to a market in Wuhan, China. The causative agent was identified as the species Severe acute respiratory syndrome-related coronavirus and was named SARS-CoV-2 (ref. ). By 16 April the virus had spread to 185 different countries, infected over 2,000,000 people and resulted in over 130,000 deaths. In the Netherlands, the first case of SARS-CoV-2 was notified on 27 February. The outbreak started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also outside, the south of the Netherlands. The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands. We demonstrate how these data were generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological data, was used to inform public health decision-making in the Netherlands.
2019 年 12 月下旬，中国武汉的一个市场报告了一组不明原因的肺炎病例。病原体被确定为严重急性呼吸综合征相关冠状病毒，并被命名为 SARS-CoV-2（参考文献）。截至 4 月 16 日，该病毒已传播到 185 个不同的国家，感染了超过 200 万人，并导致超过 13 万人死亡。在荷兰，首例 SARS-CoV-2 于 2 月 27 日报告。疫情始于意大利、奥地利、德国和法国的几个不同的引入事件，随后在荷兰南部以及之后在南部以外地区出现本地传播。全基因组序列分析和流行病学的近乎实时结合，对 SARS-CoV-2 在社区中的传播程度进行了可靠评估，有助于早期做出决策，以控制荷兰 SARS-CoV-2 的本地传播。我们展示了如何生成和分析这些数据，以及如何将 SARS-CoV-2 全基因组测序与流行病学数据相结合，为荷兰的公共卫生决策提供信息。
