O. Phipps, M.J. Brookes, and H.O. Al-Hassi are with the Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, United Kingdom.
Royal Wolverhampton Hospitals NHS Trust, Gastroenterology Unit Wolverhampton, Wolverhampton, United Kingdom.
Nutr Rev. 2021 Jan 1;79(1):88-97. doi: 10.1093/nutrit/nuaa040.
Excessive gut luminal iron contributes to the initiation and progression of colorectal cancer. However, emerging evidence suggests that reduced iron intake and low systemic iron levels are also associated with the pathogenesis of colorectal cancer. This is important because patients with colorectal cancer often present with iron deficiency. Iron is necessary for appropriate immunological functions; hence, iron deficiency may hinder cancer immunosurveillance and potentially modify the tumor immune microenvironment, both of which may assist cancer development. This is supported by studies showing that patients with colorectal cancer with iron deficiency have inferior outcomes and reduced response to therapy. Here, we provide an overview of the immunological consequences of iron deficiency and suggest ensuring adequate iron therapy to limit these outcomes.
过量的肠道内铁会导致结直肠癌的发生和发展。然而，新出现的证据表明，铁摄入减少和全身铁水平低也与结直肠癌的发病机制有关。这很重要，因为结直肠癌患者常伴有缺铁。铁是适当免疫功能所必需的；因此，缺铁可能会阻碍癌症免疫监视，并可能改变肿瘤免疫微环境，这两者都可能有助于癌症的发展。这一点得到了研究的支持，研究表明，缺铁的结直肠癌患者预后较差，对治疗的反应降低。在这里，我们概述了缺铁的免疫学后果，并建议进行适当的铁治疗以限制这些后果。
