宿主-病原体界面上蛋白质传递和营养吸收的机制。
Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface.
机构信息
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA; email:
出版信息
Annu Rev Microbiol. 2020 Sep 8;74:567-586. doi: 10.1146/annurev-micro-011720-122318. Epub 2020 Jul 17.
Abstract
Many intracellular pathogens, including the protozoan parasite , live inside a vacuole that resides in the host cytosol. Vacuolar residence provides these pathogens with a defined niche for replication and protection from detection by host cytosolic pattern recognition receptors. However, the limiting membrane of the vacuole, which constitutes the host-pathogen interface, is also a barrier for pathogen effectors to reach the host cytosol and for the acquisition of host-derived nutrients. This review provides an update on the specialized secretion and trafficking systems used by to overcome the barrier of the parasitophorous vacuole membrane and thereby allow the delivery of proteins into the host cell and the acquisition of host-derived nutrients.
摘要
许多细胞内病原体，包括原生动物寄生虫，生活在位于宿主细胞质中的液泡中。液泡的驻留为这些病原体提供了一个特定的复制场所，并防止被宿主细胞质中的模式识别受体检测到。然而，液泡的限制膜（即宿主-病原体界面）也是病原体效应物到达宿主细胞质和获取宿主来源营养物质的障碍。本综述介绍了 用于克服寄生性空泡膜障碍的特殊分泌和运输系统，从而允许蛋白质递送到宿主细胞并获取宿主来源的营养物质。
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