Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou district, Wuhan, 430030, Hubei, China.
Cancer Imaging. 2020 Jul 17;20(1):50. doi: 10.1186/s40644-020-00326-x.
The purpose of this study is to compare the diagnostic value, imaging quality and apparent diffusion coefficient (ADC) value of reduced field-of-view diffusion-weight imaging (r-FOV DWI) and full field-of-view diffusion-weight imaging (f-FOV DWI) in patients with gallbladder carcinoma and other lesions of gallbladder.
Two hundred ninety-six patients with gallbladder diseases underwent both r-FOV DWI and f-FOV DWI on a 3.0 T MRI scanner. Two radiologists assessed subjective image quality parameters independently. The Wilcoxon signed-rank test was used to compare subjective qualitative image score. Objective quality values and the mean ADC values were analyzed by paired t-test. The correlation between pathological results and mean ADC value were estimated using Spearman rank correlation analysis.
The CNR value (10.23 ± 2.92) and image quality score (13.84 ± 1.07) of r-FOV DWI were significantly higher than those of f-FOV DWI (5.24 ± 1.29 P<0.001; 10.41 ± 1.11 P<0.001). There was no significant difference between mean ADC values of the two DWI sequences for all three groups (Group 1, chronic cholecystitis; Group 2, benign lesions of gallbladder; Group 3, gallbladder carcinoma. P = 0.239, 0.974 and 0.226 respectively). For both DWI sequences, the mean ADC values were the highest in the group of cholecystitis and the lowest in the group of gallbladder carcinoma (2.49 ± 0.14 vs 1.49 ± 0.12; 2.50 ± 0.14 vs 1.50 ± 0.13, for f-FOV and r-FOV respectively), the differences among groups were statistically significant (P<0.01). The mean ADC values for both DWI sequences were negatively correlated with the group number, which increased with the malignant tendency of lesions (r = - 0.892, P<0.01; r = - 0.913, P<0.01 for f-FOV and r-FOV respectively).
Reduced Field-of-view Diffusion-weighted MRI is a good tool to diagnosis the gallbladder carcinoma, with better image quality and without affecting ADC values.
本研究旨在比较小视野扩散加权成像（r-FOV DWI）和全视野扩散加权成像（f-FOV DWI）在胆囊癌和其他胆囊病变患者中的诊断价值、成像质量和表观扩散系数（ADC）值。
296 例胆囊疾病患者在 3.0T MRI 扫描仪上同时行 r-FOV DWI 和 f-FOV DWI。两名放射科医生独立评估主观图像质量参数。采用 Wilcoxon 符号秩检验比较主观定性图像评分。采用配对 t 检验分析客观质量值和平均 ADC 值。采用 Spearman 秩相关分析估计病理结果与平均 ADC 值之间的相关性。
r-FOV DWI 的 CNR 值（10.23±2.92）和图像质量评分（13.84±1.07）明显高于 f-FOV DWI（均 P<0.001）。三组（慢性胆囊炎组、胆囊良性病变组、胆囊癌组）的两种 DWI 序列的平均 ADC 值均无统计学差异（P=0.239、0.974 和 0.226）。对于两种 DWI 序列，胆囊炎组的平均 ADC 值最高，胆囊癌组的平均 ADC 值最低（2.49±0.14 vs 1.49±0.12；2.50±0.14 vs 1.50±0.13，f-FOV 和 r-FOV 分别），组间差异具有统计学意义（均 P<0.01）。两种 DWI 序列的平均 ADC 值与组号呈负相关，随病变恶性倾向的增加而增加（r=-0.892，P<0.01；r=-0.913，P<0.01，f-FOV 和 r-FOV 分别）。
小视野扩散加权 MRI 是诊断胆囊癌的一种较好方法，具有更好的图像质量，且不影响 ADC 值。
