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使用PTW Octavius 4D对单等中心多脑转移瘤立体定向放射外科进行患者特异性剂量质量保证。

Patient-specific dose quality assurance of single-isocenter multiple brain metastasis stereotactic radiosurgery using PTW Octavius 4D.

作者信息

McCulloch James, Pawlowski Jamie, Kirby Neil, Rasmussen Karl, Shi Zheng, Myers Pamela, Stathakis Sotirios, Papanikolaou Niko, Saenz Daniel L

机构信息

Department of Radiation Oncology, University of Texas Health San Antonio, San Antonio, TX, USA.

出版信息

J Appl Clin Med Phys. 2020 Sep;21(9):107-115. doi: 10.1002/acm2.12979. Epub 2020 Jul 18.

Abstract

PURPOSE

Single-isocenter multiple brain metastasis stereotactic radiosurgery is an efficient treatment modality increasing in clinical practice. The need to provide accurate, patient-specific quality assurance (QA) for these plans is met by several options. This study reviews some of these options and explores the use of the Octavius 4D as a solution for patient-specific plan quality assurance.

METHODS

The Octavius 4D Modular Phantom (O4D) with the 1000 SRS array was evaluated in this study. The array consists of 977 liquid-filled ion chambers. The center 5.5 cm × 5.5 cm area has a detector spacing of 2.5 mm. The ability of the O4D to reconstruct three-dimensional (3D) dose was validated against a 3D gel dosimeter, ion chamber, and film measurements. After validation, 15 patients with 2-11 targets had their plans delivered to the phantom. The criteria used for the gamma calculation was 3%/1 mm. The portion of targets which were measurable by the phantom was countable. The accompanying software compiled the measured doses allowing each target to be counted from the measured dose distribution.

RESULTS

Spatial resolution was sufficient to verify the high dose distributions characteristic of SRS. Amongst the 15 patients there were 74 targets. Of the 74 targets, 61 (82%) of them were visible on the measured dose distribution. The average gamma passing rate was 99.3% (with sample standard deviation of 0.68%).

CONCLUSIONS

The high resolution provided by the O4D with 1000 SRS board insert allows for very high-resolution measurement. This high resolution in turn can allow for high gamma passing rates. The O4D with the 1000 SRS array is an acceptable method of performing quality assurance for single-isocenter multiple brain metastasis SRS.

摘要

目的

单中心多脑转移瘤立体定向放射外科是一种在临床实践中应用日益广泛的有效治疗方式。有多种方法可满足为这些治疗计划提供准确的、针对患者的质量保证(QA)的需求。本研究回顾了其中一些方法,并探讨使用Octavius 4D作为针对患者的计划质量保证的解决方案。

方法

本研究评估了配备1000 SRS阵列的Octavius 4D模块化体模(O4D)。该阵列由977个充液电离室组成。中心5.5 cm×5.5 cm区域的探测器间距为2.5 mm。通过与三维(3D)凝胶剂量计、电离室和胶片测量结果对比,验证了O4D重建三维剂量的能力。验证后,对15例有2 - 11个靶区的患者的计划在体模上进行照射。用于伽马计算的标准为3%/1 mm。体模可测量的靶区部分是可计数的。随附软件汇编测量剂量,以便从测量的剂量分布中对每个靶区进行计数。

结果

空间分辨率足以验证立体定向放射外科的高剂量分布特征。15例患者共有74个靶区。在这74个靶区中,61个(82%)在测量的剂量分布中可见。平均伽马通过率为99.3%(样本标准差为0.68%)。

结论

配备1000 SRS板插入件的O4D提供的高分辨率允许进行非常高分辨率的测量。这种高分辨率进而可实现高伽马通过率。配备1000 SRS阵列的O4D是对单中心多脑转移瘤立体定向放射外科进行质量保证的一种可接受的方法。

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