Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Dept. of Soil Science and Soil Protection, Kamýcká 129, 16500 Prague 6, Czech Republic.
University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, CZ-389 25 Vodňany, Czech Republic.
J Contam Hydrol. 2020 Oct;234:103680. doi: 10.1016/j.jconhyd.2020.103680. Epub 2020 Jul 8.
Sorption of pharmaceuticals, which can occur in soils, may differ when present in a soil solution as a single compound or in a solution with other pharmaceuticals. Therefore, the sorption isotherms described by the Freundlich equations were evaluated for 6 compounds, which were applied in solutions of a single pharmaceutical, two pharmaceuticals or all pharmaceuticals to seven soils. Study mainly focused on a behavior of fexofenadine and irbesartan that occurred in soils in 3 forms (cationic, zwitter-ionic or neutral, anionic). Sorption of both compounds slightly increased (in some soils) when applied together, largely increased when applied with carbamazepine (neutral), and extremely increased when applied in solutions with citalopram (strongly sorbed cation), which could be explained by a cooperative multilayer sorption on soil constituents. On the other hand, sorption of both compounds moderately decreased when applied with clindamycin (cation and neutral) or sulfamethoxazole (neutral or anion). The magnitude of an increase or decrease in the Freundlich sorption coefficient (K) for a particular compound depended on soil conditions, a form of compound's molecule and its interaction with molecules of other compounds. Despite sorption being influenced by other compound(s) in solution, the K coefficients evaluated for a particular compound under the different conditions were mostly correlated with the same soil properties: K with an organic carbon content, K and K with a base cation saturation, K with hydrolytic acidity, and K and K with sorption complex saturation.
药物的吸附作用可能会在土壤中发生，而当药物以单一化合物或与其他药物的混合溶液形式存在于土壤溶液中时，其吸附作用可能会有所不同。因此，我们评估了弗伦德利希方程描述的 6 种化合物在单一药物、两种药物或所有药物的溶液中对 7 种土壤的吸附等温线。本研究主要关注了非索非那定和厄贝沙坦在土壤中的 3 种形态（阳离子型、两性离子型或中性、阴离子型）的行为。当这两种化合物一起使用时，它们的吸附作用略有增加（在某些土壤中），当与卡马西平（中性）一起使用时，吸附作用大大增加，而当与西酞普兰（强吸附阳离子）一起使用时，吸附作用则极度增加，这可以用土壤成分的协同多层吸附来解释。另一方面，当与克林霉素（阳离子和中性）或磺胺甲恶唑（中性或阴离子）一起使用时，这两种化合物的吸附作用都适度降低。特定化合物的弗伦德利希吸附系数（K）增加或减少的幅度取决于土壤条件、化合物分子的形态及其与其他化合物分子的相互作用。尽管吸附作用受到溶液中其他化合物的影响，但在不同条件下评估特定化合物的 K 系数大多与相同的土壤性质相关：K 与有机碳含量相关，K 和 K 与碱基阳离子饱和度相关，K 与水解酸度相关，而 K 和 K 与吸附络合物饱和度相关。
