Department of Medical Imaging, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China; Morning Star Academic Cooperation, Shanghai, China.
Department of Ultrasonic Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Genomics. 2020 Nov;112(6):4304-4315. doi: 10.1016/j.ygeno.2020.07.026. Epub 2020 Jul 17.
The cysteinyl aspartate protease (caspase, or CASP) gene family plays a significant role in programmed cell death, inflammation and immunity. However, the correlation between CASP family members and prognosis and tumor-infiltrating lymphocytes in different tumors has not been determined. We investigated the role of CASP genes in cancer prognosis and their relationship with clinicopathological parameters. We also evaluated the correlation between the expression of CASP family members and cancer immune infiltration and evaluated whether these molecules can be used as targets for immunotherapy. The CASP1/2/4/5/7/9 genes may represent prognostic factors and therapeutic targets for breast cancer, hepatocellular carcinoma and pancreatic cancer. Another finding is that the CASP1/4/5 genes help to regulate innate immunity and T cell immunity and may also have an important effect on tumor checkpoint inhibition. These findings may elucidate the roles played by CASP family members in cancer progression and identify strategies to promote collaborative activities in the context of immunotherapy.
半胱氨酸天冬氨酸蛋白酶（caspase，或 CASP）基因家族在程序性细胞死亡、炎症和免疫中发挥重要作用。然而，CASP 家族成员与不同肿瘤中的预后和肿瘤浸润淋巴细胞之间的相关性尚未确定。我们研究了 CASP 基因在癌症预后中的作用及其与临床病理参数的关系。我们还评估了 CASP 家族成员的表达与癌症免疫浸润之间的相关性，并评估这些分子是否可以作为免疫治疗的靶点。CASP1/2/4/5/7/9 基因可能是乳腺癌、肝癌和胰腺癌的预后因素和治疗靶点。另一个发现是，CASP1/4/5 基因有助于调节先天免疫和 T 细胞免疫，对肿瘤检查点抑制也可能有重要影响。这些发现可能阐明了 CASP 家族成员在癌症进展中所起的作用，并确定了在免疫治疗背景下促进协同作用的策略。
