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在黑山,使用疾病修正药物的复发缓解型多发性硬化症患者对 COVID-19 大流行的态度。

Attitudes of patients with relapsing-remitting form of multiple sclerosis using disease-modifying drugs in Montenegro regarding COVID-19 pandemic.

机构信息

Clinical Centre of Montenegro, Clinic for Neurology, Ljubljanska bb, 81000 Podgorica, Montenegro; University of Montenegro, Faculty of Medicine, Department for Neurology, Krusevac bb, 81000 Podgorica, Montenegro.

Clinical Centre of Montenegro, Clinic for Neurology, Ljubljanska bb, 81000 Podgorica, Montenegro.

出版信息

Mult Scler Relat Disord. 2020 Oct;45:102380. doi: 10.1016/j.msard.2020.102380. Epub 2020 Jul 6.

DOI:10.1016/j.msard.2020.102380
PMID:32683304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7341967/
Abstract

BACKGROUND

In the days of the reorganization of healthcare systems due to SARS-Cov2 pandemic, patients suffering from chronic diseases are being often neglected. The aim of our study was to examine the attitudes and behaviors of patient suffering from relapsing-remitting form of multiple sclerosis using disease-modifying drugs in Montenegro in relation to the current pandemic.

METHODS

The research was conducted through an online-generated questionnaire during the peak of the pandemic.

RESULTS

There is a high level of concern about COVID-19 (3.22±1.23), especially about safety behavior intensification (3.80±1.29). Possibility of relapse during pandemic was considered as moderate (2.06±1.42), but relapse symptoms would be reported by the majority of subjects (1.55±1.23). Our unemployed patients statistically more often reported that they had more frequent mood changes, but also that they felt more energy loss. Surprisingly, there was no difference among the subjects according to smoking status. According therapy groups there was significant difference between the groups regarding some variables: patients using ocrelizumab are most concerned about COVID-19; patients using interferon beta 1a i.m. statistically more often have frequent changes in their mood, memory problems, poor appetite, feeling of nausea or upset stomach and patients on fingolimod have bigger afraid of coming to regular visits.

CONCLUSION

Our patients showed concern about their disease future status in the current epidemic era, but also showed a high degree of trust in physicians and the overall health system.

摘要

背景

在因 SARS-CoV2 大流行而进行医疗体系重组的时期,慢性疾病患者往往被忽视。我们的研究旨在考察在当前大流行背景下,使用疾病修正药物的多发性硬化症缓解复发型患者的态度和行为。

方法

该研究通过在线生成的问卷在疫情高峰期进行。

结果

患者对 COVID-19 有高度关注(3.22±1.23),特别是对强化安全行为的关注(3.80±1.29)。大多数患者认为在大流行期间有中度的复发可能性(2.06±1.42),但会报告复发症状。我们的失业患者更频繁地报告情绪变化,但也感到能量损失增加。令人惊讶的是,根据吸烟状况,患者之间没有差异。根据治疗组,各组之间在一些变量方面存在显著差异:使用奥瑞珠单抗的患者对 COVID-19 最为担忧;使用干扰素β1a 的患者更频繁地出现情绪变化、记忆力问题、食欲不振、恶心或胃部不适,而使用芬戈莫德的患者更害怕定期就诊。

结论

我们的患者对当前疫情时代疾病未来状况表示关注,但对医生和整体医疗体系表现出高度信任。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/307986091bc1/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/23e4d4871826/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/96536eae56d5/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/307986091bc1/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/23e4d4871826/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/96536eae56d5/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c32/7341967/307986091bc1/gr3_lrg.jpg

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The COVID-19 pandemic and the use of MS disease-modifying therapies.新冠疫情与多发性硬化症疾病修正疗法的使用
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