Hu Xiaoyan, Gou Jie, Guo Liang
Department of Radiology, Chengdu First People's Hospital, 18 Wanxiang North Road, Chengdu, 610000, Sichuan Province, China.
The Public Health Clinical Center of Chengdu, 18 Jingjusi Road, Chengdu, 610000, Sichuan Province, China.
Radiol Case Rep. 2020 Jun 19;15(9):1609-1613. doi: 10.1016/j.radcr.2020.06.031. eCollection 2020 Sep.
Since December 2019, a new type of acute respiratory disease caused by the 2019 novel coronavirus (COVID-19) appeared to Wuhan, China. Currently, positive of virus nucleic acid in respiratory or blood samples is the gold standard for the diagnosis of the disease, but the nucleic acid test may be false negative. Chest CT examination plays an important role in diagnosis of COVID-19 pneumonia. The clinical manifestations, laboratory examination, and chest CT characteristics of 3 patients with COVID-19 pneumonia were reported. The mainly clinical manifestation of the 3 patients was fever. White blood cell, neutrophil cell, and lymphocyte cell count can be normal, only C-reactive protein slightly elevated. Real-time fluorescence polymerase chain reaction of throat swab detection can be negative. Chest CT showed multifocal ground-glass opacities in the peripheral of bilateral lungs. Ground-glass opacities with consolidation, air bronchogram, vascular enlargement, and halo sign were found. In the early stages of COVID-19 pneumonia, the laboratory parameters may be normal, the nucleic acid test may be false negative. Chest CT examination may be helpful for diagnosis of COVID-19 pneumonia.
自2019年12月以来，一种由2019新型冠状病毒（COVID-19）引起的新型急性呼吸道疾病在中国武汉出现。目前，呼吸道或血液样本中病毒核酸呈阳性是该疾病诊断的金标准，但核酸检测可能会出现假阴性。胸部CT检查在COVID-19肺炎的诊断中起着重要作用。报告了3例COVID-19肺炎患者的临床表现、实验室检查及胸部CT特征。这3例患者的主要临床表现为发热。白细胞、中性粒细胞和淋巴细胞计数可正常，仅C反应蛋白略有升高。咽拭子检测的实时荧光聚合酶链反应可为阴性。胸部CT显示双肺外周多发磨玻璃影。可见磨玻璃影合并实变、空气支气管征、血管增粗及晕征。在COVID-19肺炎的早期，实验室指标可能正常，核酸检测可能为假阴性。胸部CT检查可能有助于COVID-19肺炎的诊断。
