Liu Song, Wang Quan, Zhang Geng, Du Jian, Hu Bingliang, Zhang Zhoufeng
Key Laboratory of Spectral Imaging Technology of CAS, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Anal Methods. 2020 Aug 14;12(30):3844-3853. doi: 10.1039/d0ay01023e. Epub 2020 Jul 20.
The gastric cancer grading of patients determines their clinical treatment plan. We use hyperspectral imaging (HSI) gastric cancer section data to automatically classify the three different cancer grades (low grade, intermediate grade, and high grade) and healthy tissue. This paper proposed the use of HSI data combined with a shallow residual network (SR-Net) as the classifier. We collected hyperspectral data from gastric sections of 30 participants, with the wavelength range of hyperspectral data being 374 nm to 990 nm. We compared the classification results between hyperspectral data and color images. The results show that using hyperspectral data and a SR-Net an average classification accuracy of 91.44% could be achieved, which is 13.87% higher than that of the color image. In addition, we applied a modified SR-Net incorporated direct down-sampling, asymmetric filters, and global average pooling to reduce the parameters and floating-point operations. Compared with the regular residual network with the same number of blocks, the floating-point operations of a SR-Net are one order of magnitude less. The experimental results show that hyperspectral data with a SR-Net can achieve cutting-edge performance with minimum computational cost and therefore have potential in the study of gastric cancer grading.
患者的胃癌分级决定了他们的临床治疗方案。我们使用高光谱成像(HSI)胃癌切片数据对三种不同的癌症分级(低级别、中级别和高级别)以及健康组织进行自动分类。本文提出使用HSI数据结合浅层残差网络(SR-Net)作为分类器。我们收集了30名参与者胃部切片的高光谱数据,高光谱数据的波长范围为374纳米至990纳米。我们比较了高光谱数据和彩色图像之间的分类结果。结果表明,使用高光谱数据和SR-Net可实现平均分类准确率91.44%,比彩色图像高出13.87%。此外,我们应用了一种改进的SR-Net,它结合了直接下采样、非对称滤波器和全局平均池化来减少参数和浮点运算。与具有相同块数的常规残差网络相比,SR-Net的浮点运算减少了一个数量级。实验结果表明,结合SR-Net的高光谱数据能够以最低的计算成本实现前沿性能,因此在胃癌分级研究中具有潜力。