State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024, China.
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Angew Chem Int Ed Engl. 2020 Nov 2;59(45):20008-20016. doi: 10.1002/anie.202006649. Epub 2020 Sep 15.
The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O produced by the PDT is converted to H O by superoxide dismutase, followed by the transformation of H O to the highly toxic OH via Fenton reactions by Fe originating from the dissolution of co-loaded Fe O nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O source for production of OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.
由于实体瘤的缺氧特征，光动力疗法（PDT）的抗癌效果有限。我们通过整合串联芬顿反应报告协同 PDT/化疗，该反应由卵清蛋白包封介导，通过增强活性氧（ROS）生成机制来改善体内抗癌治疗。PDT 产生的 O 通过超氧化物歧化酶转化为 H2O2，随后通过来自共负载的 Fe2O3 纳米颗粒溶解的 Fe 引发的芬顿反应将 H2O2 转化为剧毒的·OH。PDT 过程进一步促进了活性物质的内体/溶酶体逃逸，并增强了它们向细胞核的细胞内传递，即使是耐药细胞也是如此。顺铂在烟酰胺腺嘌呤二核苷酸磷酸氧化酶的存在下产生 O，从而通过充当·OH 自由基生成的额外 O 源来提高治疗效率。在缺氧和常氧条件下都能实现更好的抗癌效果。
