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[几个欧洲国家协调开展的狐狸口服抗狂犬病疫苗接种经验及重组痘苗狂犬病病毒使用前景]

[Experience with antirabies vaccination of foxes using the oral route coordinated among several European countries and perspectives on the use of recombinant vaccinia-rabies virus].

作者信息

Pastoret P P, Blancou J, Brochier B, Thomas I, Paquot A, Debruyn J, Costy F, Wolff F, Kieny M P, Languet B

机构信息

Département de Virologie-Immunologie et Pathologie des Maladies Virales, Faculté de Médecine Vétérinaire, Bruxelles, Belgique, France.

出版信息

Parassitologia. 1988 Jan-Apr;30(1):149-54.

PMID:3268767
Abstract

Campaigns of fox vaccination against rabies were carried out in Belgium, grand-duchy of Luxembourg and France in September 1986, June and September 1987. The SAD B19 attenuated strain of rabies virus, contained in baits (Tübingen baits) was used as vaccine. Baits were distributed at a range density of 11 to 15 baits per km2. First results are very encouraging. A recombinant vaccinia virus harbouring the rabies virus glycoprotein gene has been developed. This recombinant virus can be given to the fox by the oral route and protects it against rabies virus challenge; it is also innocuous for the fox and other non-target European species. A first trial of fox vaccination against rabies using this recombinant vaccinia-rabies virus has been carried out in Belgium, on a military domain, in October 1987.

摘要

1986年9月、1987年6月和9月,比利时、卢森堡大公国和法国开展了狐狸狂犬病疫苗接种活动。诱饵(图宾根诱饵)中含有的狂犬病病毒SAD B19减毒株被用作疫苗。诱饵的投放密度为每平方公里11至15个。初步结果非常令人鼓舞。一种携带狂犬病病毒糖蛋白基因的重组痘苗病毒已研制成功。这种重组病毒可以通过口服途径给予狐狸,并保护其免受狂犬病病毒攻击;它对狐狸和其他非目标欧洲物种也无害。1987年10月,在比利时的一个军事区域,首次使用这种重组痘苗狂犬病病毒进行了狐狸狂犬病疫苗接种试验。

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