State Key Laboratory Base for Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao, 266042, China.
College of Life Sciences, Qingdao University, Qingdao, China.
Eur J Med Chem. 2020 Oct 1;203:112506. doi: 10.1016/j.ejmech.2020.112506. Epub 2020 Jun 28.
With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives. Combining structure activity relationships and molecular targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents.
一些吲哚和氮茚类化合物已成功开发为抗癌药物，因此，具有显著抗肿瘤活性的吲哚和氮茚类衍生物的设计和合成受到了越来越多的关注，并取得了显著的进展。本文综述了近年来抗癌吲哚和氮茚衍生物在肿瘤发生、作用机制和构效关系方面的研究进展。本文结合构效关系和与分子靶标相关的知识，将有助于研究人员设计更有效、安全和经济有效的抗癌吲哚和氮茚类药物。
